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dc.contributor.authorValcárcel, J.es_ES
dc.contributor.authorGarcía, Miriam R.es_ES
dc.contributor.authorSampayo, Lucía F.es_ES
dc.contributor.authorVázquez, José Antonioes_ES
dc.date.accessioned2019-10-28T12:16:18Z-
dc.date.available2019-10-28T12:16:18Z-
dc.date.issued2020-
dc.identifier.citationCarbohydrate Polymers 229: 115450 (2020)es_ES
dc.identifier.issn0144-8617-
dc.identifier.urihttp://hdl.handle.net/10261/193588-
dc.description9 pages, 4 figures, 4 tableses_ES
dc.description.abstractChondroitin sulfate (CS) is a sulfated glycosaminoglycan with diverse biological activities, which are influenced by molecular weight (Mw) and sulfation pattern. In the present work, we take advantage of the characteristic high Mw of fish CS (51–70 kDa) to obtain lower Mw fragments with hyaluronidase and chondroitinase ABC. With this aim, we present a pseudo-mechanistic model capable of reproducing the decrease in Mw of CS from five different fish species over 24 h at four enzyme to substrate ratios. The fitting parameters of the model for each species allow to establish conditions of reaction to produce CS of the desired Mw. Furthermore, the main features of the sulfation pattern of fish CS remain in the depolymerized fragments, highlighting the feasibility of the proposed approaches_ES
dc.description.sponsorshipThis study was financed by projects IBEROS (0245_IBEROS_1_E, POCTEP 2015), CVMar+I (0302_CVMAR_I_1_P, POCTEP 2015), BLUEHUMAN (EAPA_151/2016, UE-INTERREG Atlantic Area Programme) and Xunta de Galicia (Grupos de Potencial Crecimiento, IN607B 2018/19). M.R.G thanks RTI2018-093560-J-I00 (MCIU/AEI/FEDER, UE)es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rightsembargoedAccesses_ES
dc.subjectChondroitin sulfatees_ES
dc.subjectGlycosaminoglycanes_ES
dc.subjectHyaluronidasees_ES
dc.subjectChondroitinasees_ES
dc.subjectEnzymatic depolymerizationes_ES
dc.subjectDepolymerization kineticses_ES
dc.titleMarine chondroitin sulfate of defined molecular weight by enzymatic depolymerizationes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.carbpol.2019.115450-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.carbpol.2019.115450es_ES
dc.identifier.e-issn1879-1344-
dc.embargo.terms2021-02-01es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
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