Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/193588
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Marine chondroitin sulfate of defined molecular weight by enzymatic depolymerization |
Autor: | Valcárcel Barros, Jesús CSIC ORCID; García, Miriam R. CSIC ORCID ; Sampayo, Lucía F. CSIC; Vázquez, José Antonio CSIC ORCID | Palabras clave: | Chondroitin sulfate Glycosaminoglycan Hyaluronidase Chondroitinase Enzymatic depolymerization Depolymerization kinetics |
Fecha de publicación: | 2020 | Editor: | Elsevier | Citación: | Carbohydrate Polymers 229: 115450 (2020) | Resumen: | Chondroitin sulfate (CS) is a sulfated glycosaminoglycan with diverse biological activities, which are influenced by molecular weight (Mw) and sulfation pattern. In the present work, we take advantage of the characteristic high Mw of fish CS (51–70 kDa) to obtain lower Mw fragments with hyaluronidase and chondroitinase ABC. With this aim, we present a pseudo-mechanistic model capable of reproducing the decrease in Mw of CS from five different fish species over 24 h at four enzyme to substrate ratios. The fitting parameters of the model for each species allow to establish conditions of reaction to produce CS of the desired Mw. Furthermore, the main features of the sulfation pattern of fish CS remain in the depolymerized fragments, highlighting the feasibility of the proposed approach | Descripción: | 9 pages, 4 figures, 4 tables | Versión del editor: | https://doi.org/10.1016/j.carbpol.2019.115450 | URI: | http://hdl.handle.net/10261/193588 | DOI: | 10.1016/j.carbpol.2019.115450 | ISSN: | 0144-8617 | E-ISSN: | 1879-1344 |
Aparece en las colecciones: | (IIM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Marine_chondroitin_sulfate_2020.pdf | 3,6 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
13
checked on 18-abr-2024
WEB OF SCIENCETM
Citations
10
checked on 22-feb-2024
Page view(s)
275
checked on 24-abr-2024
Download(s)
266
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.