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http://hdl.handle.net/10261/193354
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Medina-Gali, Regla María | es_ES |
dc.contributor.author | Belló Pérez, Melissa | es_ES |
dc.contributor.author | Martínez-López, Alicia | es_ES |
dc.contributor.author | Falcó, Alberto | es_ES |
dc.contributor.author | Ortega-Villaizán, M. M. | es_ES |
dc.contributor.author | Encinar, José Antonio | es_ES |
dc.contributor.author | Novoa, Beatriz | es_ES |
dc.contributor.author | Coll Morales, Julio | es_ES |
dc.contributor.author | Pérez, L. | es_ES |
dc.date.accessioned | 2019-10-24T11:50:49Z | - |
dc.date.available | 2019-10-24T11:50:49Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Fish and Shellfish Immunology 82: 514-521 (2018) | es_ES |
dc.identifier.issn | 1050-4648 | - |
dc.identifier.uri | http://hdl.handle.net/10261/193354 | - |
dc.description | 8 pages, 4 figures, 1 table | es_ES |
dc.description.abstract | Chromatin immunoprecipitation (ChIP) and high throughput sequencing (ChIP-seq) have been used to assess histone methylation (epigenetic modification) dynamics within the internal organs of zebrafish after spring viremia of carp virus (SVCV) infection. Our results show H3K4me3 up-methylation in gene promoters associated with innate immune response during the first 5 days after SVCV infection. Gene Ontology (GO) enrichment analysis confirmed up-methylation in 218 genes in the “immune system process” category. In particular, the promoters of interferon (ifn), interferon stimulated genes (isg), Toll-like receptors (tlr) and c-reactive protein (crp) multi gene sets were marked with the permissive H3K4 methylation. Higher histone 3 methylation was associated with higher transcription levels of the corresponding genes. Therefore, the evidence presented here suggests that transcriptional regulation at the promoter level of key immune genes of the interferon signaling pathway and c-reactive proteins genes can be modulated by epigenetic modification of histones. This study emphasizes the importance of epigenetic control in the response of zebrafish to SVCV infection | es_ES |
dc.description.sponsorship | This study was supported by Spanish Ministerio de Educación y Competitividad Grant AGL2014-51773-C3 and grant BIO2017-82851-C3-1-R. Dr. Ortega-Villaizán is the holder of ERC Starting Grant 2014 GA639249. Melissa Belló-Pérez is the holder of GVAL fellowship ACIF/2016/207 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-51773-C3-2-R | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Zebrafish | es_ES |
dc.subject | SVCV | es_ES |
dc.subject | Histone methylation | es_ES |
dc.subject | ChIP-seq | es_ES |
dc.subject | Innate immunity | es_ES |
dc.title | Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.fsi.2018.08.056 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.fsi.2018.08.056 | es_ES |
dc.identifier.e-issn | 1095-9947 | - |
dc.embargo.terms | 2019-11-01 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Chromatin_immunoprecipitation_2018.pdf | 3,39 MB | Adobe PDF | Visualizar/Abrir |
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