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Novel gold(I) 7-azacoumarin complex: Synthesis, structure, optical properties, and cytotoxic effects

AuthorsCasas, José S.; Castellano, Eduardo E.; Couce, María D.; Crespo, Olga ; Ellena, Javier; Laguna, Antonio ; Sánchez, Agustin; Sordo, José; Taboada, Carmen
Issue Date30-Jun-2007
PublisherAmerican Chemical Society
CitationInorg. Chem. 46(16): 6236–6238 (2008)
AbstractA mixture of pyridoxalrhodanine, triethylphosphinegold(I) chloride, and sodium methoxide in methanol unexpectedly afforded the azacoumarin complex [Au(TS)(PEt3)] [HTS = 5-(hydroxymethyl)-8-methyl-3-thiol-7-azacoumarin], which was characterized by X-ray diffractometry. Its crystals consist of independent molecules in which the metal atom is bound to the azacoumarin [Au−S = 2.9458(18) Å] and the phosphine [Au−P = 2.262(2) Å] in an almost linear arrangement [P1−Au1−S1 = 176.93(7)°]. The complex showed better in vitro antitumor activity than cisplatin against the cisplatin-resistant cell line A2780cis.
Description3 pages, 2 tables, 1 scheme, 1 figure.
Publisher version (URL)http://dx.doi.org/10.1021/ic700861a
Appears in Collections:(ICMA) Artículos
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