English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/192675
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Identification and validation of common molecular targets of hydroxytyrosol

AuthorsLópez de las Hazas, M. C.; Martín-Hernández, Roberto; Crespo, M.C.; Tomé-Carneiro, Joao ; del Pozo-Acebo, L.; Escolà-Gil, Joan Carles; Osada, Jesús; Portillo, Mariá Puy; Navarro, María Ángeles; Martínez, J. Alfredo; Rubió, Laura; Motilva, Maria-José; Visioli, Francesco; Dávalos, Alberto
Issue Date15-Jul-2019
PublisherRoyal Society of Chemistry (UK)
CitationFood and Function 10(8): 4897-4910 (2019)
AbstractHydroxytyrosol (HT) is involved in healthful activities and is beneficial to lipid metabolism. Many investigations focused on finding tissue-specific targets of HT through the use of different omics approaches such as transcriptomics and proteomics. However, it is not clear which (if any) of the potential molecular targets of HT reported in different studies are concurrently affected in various tissues. Following the bioinformatic analyses of publicly available data from a selection of in vivo studies involving HT-supplementation, we selected differentially expressed lipid metabolism-related genes and proteins common to more than one study, for validation in rodent liver samples from the entire selection. Four miRNAs (miR-802-5p, miR-423-3p, miR-30a-5p, and miR-146b-5p) responded to HT supplementation. Of note, miR-802-5p was commonly regulated in the liver and intestine. Our premise was that, in an organ crucial for lipid metabolism such as the liver, consistent modulation should be found for a specific target of HT even if different doses and duration of HT supplementation were used in vivo. Even though our results show inconsistency regarding differentially expressed lipid metabolism-related genes and proteins across studies, we found Fgf21 and Rora as potential novel targets of HT. Omics approaches should be fine-tuned to better exploit the available databases.
URIhttp://hdl.handle.net/10261/192675
DOI10.1039/c9fo01159e
ISSN2042-6496
E-ISSN2042-650X
Appears in Collections:(ICVV) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,35 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.