Please use this identifier to cite or link to this item:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Influence of thermal processing on the phase behavior of a novel acylglyceride-alkylglyceride lipid-based delivery system

AuthorsArranz-Martínez, Pablo ; Corzo-Martínez, Marta CSIC ORCID; Vázquez de Frutos, Luis ; Torres, Carlos F. CSIC ORCID ; Marangoni, Alejandro G.
Issue Date2018
PublisherRoyal Society of Chemistry (UK)
CitationFood and Function 9(7): 4028-4035 (2018)
AbstractLipid-based delivery systems have been broadly utilized to enhance bioavailability and bioaccessibility properties of drugs. Loading capacity and drug stability within the lipid matrix is influenced by the phase behavior of the lipid components that make up the vehicle. In this study we have investigated the influence of thermal processing at 50 °C on the subsequent phase behavior of a lipid-based delivery system comprised of a blend of monoacylglycerols, diacylglycerols, monoalkylglycerols and dialkylglycerols obtained by enzymatic glycerolysis of ratfish liver oil. Differential scanning calorimetry revealed that crystallization and melting points decreased, while powder X-ray diffraction suggested changes in the crystal structure of the product when heated to 50 °C and held for longer than 180 min. Samples heated for a short time, rapidly underwent a polymorphic transition from the α to the β polymorphic phase, whereas samples heated for long times remained in the α phase for 3 days. Polarized light microscopy also showed changes in the microstructure of the material due to the thermal treatment. These results suggest that the thermal history of lipidic encapsulation materials, above their melting point, can affect eventual encapsulation efficiency and product performance.
Publisher version (URL)
Appears in Collections:(CIAL) Artículos

Files in This Item:
File Description SizeFormat
accesoRestringido.pdf59,24 kBAdobe PDFThumbnail
Show full item record
Review this work

Page view(s)

checked on Jan 24, 2022


checked on Jan 24, 2022

Google ScholarTM




WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.