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Serum metabolome of fasted gilthead sea bream. A non-targeted approach for the identification of robust biomarkers of malnutrition in fish

AuthorsGil-Solsona, Ruben; Nácher-Mestre, Jaime; Sancho, Juan Vicente; Calduch-Giner, Josep A. CSIC ORCID; Hernández Hernández, Félix; Pérez-Sánchez, Jaume CSIC ORCID
Issue Date2017
PublisherUniversidad Jaume I
CitationAdvances in comparative endocrinology: vol. VIII: 59-62 (2017)
AbstractThe study assessed the metabolomic fingerprinting of fasted gilthead sea bream by means of ultra-high performance liquid chromatography (LC) coupled to quadrupole time-of-flight mass spectrometry (QTOF MS). More than 15,000 different m/z ions were represented in the analyzed samples and discriminant analysis (PLS-DA) allowed a clear differentiation between the two experimental groups (fed and 10-days fasted fish), explaining the first component more than 90% of total variance. The most significant metabolites (up to 45) were elucidated based on their tandem MS (MS/MS) spectra with a broad representation of amino acids, oligopeptides, urea cycle metabolites, Lcarnitine-related metabolites, glutathione-related metabolites, fatty acids, lysophosphatidic acids, phosphatidylcholines, and biotine and noradrenaline metabolites. This highlighted important adaptive response in energy and oxidative metabolism, contributing this non-targeted approach to identify robust and nutritionallyregulated biomarkers of health and metabolic condition in farmed fish
DescriptionTrabajo presentado en el 11º Congreso de la Asociación Ibérica de Endocrinología Comparada (AIEC), celebrado en Vigo (España), del 13 al 15 de julio de 2017
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