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http://hdl.handle.net/10261/191990
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dc.contributor.author | Lucas-Gil, Eva de | - |
dc.contributor.author | Leret, Pilar | - |
dc.contributor.author | Monte-Serrano, Mercedes | - |
dc.contributor.author | Jiménez Reinosa, Julián | - |
dc.contributor.author | Enríquez Pérez, Esther | - |
dc.contributor.author | Campo, Ángel Adolfo del | - |
dc.contributor.author | Cañete, Magdalena | - |
dc.contributor.author | Menéndez, Javier | - |
dc.contributor.author | Fernández Lozano, José Francisco | - |
dc.contributor.author | Rubio Marcos, Fernando | - |
dc.date.accessioned | 2019-10-01T12:05:40Z | - |
dc.date.available | 2019-10-01T12:05:40Z | - |
dc.date.issued | 2018 | - |
dc.identifier | doi: 10.1021/acsanm.8b00402 | - |
dc.identifier | issn: 2574-0970 | - |
dc.identifier.citation | ACS Applied Nano Materials 1: 3214- 3225 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/191990 | - |
dc.description.abstract | The extensive range of applications where synthetic nanomaterials are nowadays used is causing a huge commercial market. An incipient use of these nanomaterials arises from the need to generate alternative antimicrobial agents, anticipating the development of resistant micro- organisms. Here, we show a nanostructured ZnO with antimicrobial properties and low cytotoxicity based on a nanoparticle¿s arrangement by controlling the formation of sintering neck into nanoporous spheres. The antimicrobial effectiveness of ZnO spheres is tested in a broad spectrum of microorganisms such as fungi as well as Gram-negative and Gram-positive bacteria. The hierarchical structures show highly effective antimicrobial activity at low concentrations and in relatively short action times (24¿72 h). We demonstrate that the enhanced antimicrobial properties against microorganisms are ascribed to a combining of both physical and chemical interactions between microorganism and ZnO. The approximation mechanism between microorganism and ZnO is provided through electrostatic forces (physical interaction) which, thanks to the ZnO¿microorganism proximity, promote a rapid release of zinc cations and the reactive oxygen species penetration into microorganisms (chemical interaction). We believe that this work provides insights into the mechanisms underlying the interactions ZnO¿microorganism and possesses a combined action mechanism for which nanostructured ZnO is so effective to combat microorganisms. | - |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) under the projects MAT2017-86450-C4-1-R, and the Spanish National Research Council (CSIC) under the project NANOMIND CSIC 201560E068. Dr. P. Leret is also indebted to MINECO for a “Torres Quevedo” contract (ref: PTQ-12-05470), which is cofinanced with European Social Fund. Dr. E. Enriquez is also indebted to MINECO for a ‘‘Torres Quevedo’’ contract (ref: PTQ-14-07289), which is co-financed with European Social Fund. Dr. F. R-M is also indebted to MINECO for a ‘Ramon y Cajal’ contract (ref: RyC-2015-18626), which is co-financed by the European Social. The authors acknowledge the ESRF The European Synchrotron and the SpLine CRG BM25 beamline staff for provision of synchrotron radiation and for assistance during X-ray diffraction measurements (ref: 25-01-966). Finally, authors are grateful to Aida Serrano and Rocío Estefanía Rojas-Hernandez for scientific and technical advice in XANES measurements, Mª José Velasco and Pilar Ortega for ICP-OES measurements, Alexandra Muñoz-Bonilla for scientific advice and Laura Pascual for scientific and technical advice | - |
dc.publisher | American Chemical Society | - |
dc.relation | MAT2017-86450-C4-1-R/AEI/10.13039/501100011033 | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/MAT2017-86450-C4-1-R | - |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | - |
dc.subject | Physicochemical action | - |
dc.subject | Antimicrobial properties | - |
dc.subject | Nanoporous spheres | - |
dc.subject | ZnO | - |
dc.subject | Cluster | - |
dc.title | ZnO Nanoporous Spheres with Broad-Spectrum Antimicrobial Activity by Physicochemical Interactions | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1021/acsanm.8b00402 | - |
dc.relation.publisherversion | https://doi.org/10.1021/acsanm.8b00402 | - |
dc.date.updated | 2019-10-01T12:05:40Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | © 2018 American Chemical Society | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.contributor.orcid | Lucas-Gil, Eva de [0000-0001-5894-9866] | - |
dc.contributor.orcid | Fernández Lozano, José Francisco [0000-0001-5894-9866] | - |
dc.contributor.orcid | Rubio Marcos, Fernando [0000-0002-2479-3792] | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
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