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ZnO Nanoporous Spheres with Broad-Spectrum Antimicrobial Activity by Physicochemical Interactions

AuthorsLucas-Gil, Eva de; Leret, Pilar ; Monte-Serrano, Mercedes; Reinosa, Julián J.; Enríquez Pérez, Esther ; Campo, Ángel Adolfo del ; Cañete, Magdalena; Menéndez, Javier ; Fernández Lozano, José Francisco ; Rubio Marcos, Fernando
KeywordsPhysicochemical action
Antimicrobial properties
Nanoporous spheres
Issue Date2018
PublisherAmerican Chemical Society
CitationACS Applied Nano Materials 1: 3214- 3225 (2018)
AbstractThe extensive range of applications where synthetic nanomaterials are nowadays used is causing a huge commercial market. An incipient use of these nanomaterials arises from the need to generate alternative antimicrobial agents, anticipating the development of resistant micro- organisms. Here, we show a nanostructured ZnO with antimicrobial properties and low cytotoxicity based on a nanoparticle¿s arrangement by controlling the formation of sintering neck into nanoporous spheres. The antimicrobial effectiveness of ZnO spheres is tested in a broad spectrum of microorganisms such as fungi as well as Gram-negative and Gram-positive bacteria. The hierarchical structures show highly effective antimicrobial activity at low concentrations and in relatively short action times (24¿72 h). We demonstrate that the enhanced antimicrobial properties against microorganisms are ascribed to a combining of both physical and chemical interactions between microorganism and ZnO. The approximation mechanism between microorganism and ZnO is provided through electrostatic forces (physical interaction) which, thanks to the ZnO¿microorganism proximity, promote a rapid release of zinc cations and the reactive oxygen species penetration into microorganisms (chemical interaction). We believe that this work provides insights into the mechanisms underlying the interactions ZnO¿microorganism and possesses a combined action mechanism for which nanostructured ZnO is so effective to combat microorganisms.
Publisher version (URL)https://doi.org/10.1021/acsanm.8b00402
Identifiersdoi: 10.1021/acsanm.8b00402
issn: 2574-0970
Appears in Collections:(ICV) Artículos
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