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Effects of xenoestrogen exposure during immune system ontogenesis of the European sea bass, Dicentrarchus labrax (L.)

AuthorsMoreira, Catarina; Paiola, Matthieu; Pinto, Patrícia I. S.; Pozo, R. del; Piazzon de Haro, María Carla ; Knigge, Thomas; Fouz, B.; Varó, Inmaculada ; Sitjà-Bobadilla, Ariadna ; Monsinjon, Tiphaine
Issue Date10-Sep-2018
Citation31st ESCBPC (2018)
AbstractThe farming of fish inflicts various stresses upon the animals, which may impact their immune system. A reduced capacity to fight pathogenic agents may entail important losses in aquaculture production. Oestrogens are well-known endocrine disruptors that are present in natural forms in fish farms because non-degraded hormones, such as oestradiol, are released by the fish into the water body. Oestradiol is involved in the regulation of numerous physiological functions, including the modulation of immune system function and performance. Hence, we studied the long-term consequences of exposure to environmentally relevant concentrations of oestradiol on fish immunocompetence. Fingerlings of 47 and 60 days post-hatch were exposed to 20ng/L of oestradiol for 7 days and one month, respectively. Water samples were collected and analyzed by radioimmunoassays. Following exposure, each stage was sampled for gene expression analysis to assess the impacts of oestradiol on the ontogenesis of the thymus, which is the primary lymphoid organ responsible for T cell differentiation. After depuration phase, the fish were challenged by intracoelomic injection with Vibrio harveyi and cumulative mortality was recorded. Exposure to oestradiol, which was detected in the exposure water, from 47 to 54 days post-hatch caused an increase in sea bass mortality following bacterial challenge. By contrast, oestradiol exposure from 60 to 90 days post-hatch improved the fish resistance to vibriosis. As in mammals, oestradiol seems to have immunostimulating or immunosuppressive effects depending on the critical window of development. The relation between these immunomodulatory effects, thymus development and associated peripheral T cells is currently investigated.
DescriptionTrabajo presentado en el 31st European Society of Comparative Biochemistry and Physiology Congress (ESCBPC), celebrado en Oporto (Portugal), del 9 al 12 de septiembre de 2018
Appears in Collections:(IATS) Comunicaciones congresos
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