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Targeting proteins to RNA transcription and processing sites within the nucleus

Other TitlesConferencia: 1st International Caparica Conference in Splicing (SPLICING)
AuthorsSánchez-Hernández, Noemí; Prieto-Sánchez, Silvia; Moreno-Castro, Cristina; Muñoz-Cobo, Juan Pablo; El Yousfi, Younes; Boyero-Corral, Sofía; Suñé-Pou, Marc; Hernández-Munaín, Cristina; Suñé, Carlos
KeywordsNuclear organization
Nuclear bodies
Nuclear speckles
Targeting signal
Issue DateOct-2017
CitationInternational Journal of Biochemistry and Cell Biology
AbstractStudies of the spatial organization of the highly compartmentalized eukaryotic nucleus and dynamics of transcription and RNA processing within it are fundamental for fully understanding how gene expression is regulated in the cell. Although some progress has been made in deciphering the functional consequences of this complex network of interacting molecules in the context of nuclear organization, how proteins and RNA move in the nucleus and how the transcription and RNA processing machineries find their targets are important questions that remain largely unexplored. Here, we review major hallmarks and novel insights regarding the movement of RNA and proteins in the context of nuclear organization as well as the mechanisms by which the proteins involved in RNA processing localize to specific nuclear compartments.
DescriptionConferencia: 1st International Caparica Conference in Splicing (SPLICING) Ubicación: Lisbon, PORTUGAL Fecha: SEP 12-14, 2016 Patrocinador(es):BRUKER; Elsevier; ThermoFisher Sci; RNA Soc; STAB Vida
Appears in Collections:(IPBLN) Comunicaciones congresos
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