English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/191423
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Synthesis, neuroprotective and antioxidant capacity of PBN-related indanonitrones

AuthorsJimenez-Almarza A.; Diez-Iriepa, Daniel; Chioua, Mourad ; Chamorro B.; Iriepa, Isabel; Martínez-Murillo, Ricardo ; Hadjipavlou-Litina, Dimitra; Oset-Gasque, María Jesús; Marco-Contelles, José
KeywordsLipid peroxidation
Lipoxygenase inhibitors
Issue Date2019
PublisherAcademic Press
CitationBioorganic Chemistry 86: 445-451 (2019)
AbstractIn this work six PBN-related indanonitrones 1–6 have been designed, synthesized, and their neuroprotection capacity tested in vitro, under OGD conditions, in SH-SY5Y human neuroblastoma cell cultures. As a result, we have identified indanonitrones 1, 3 and 4 (EC50=6.64 ± 0.28 μM) as the most neuroprotective agents, and in particular, among them, indanonitrone 4 was also the most potent and balanced nitrone, showing antioxidant activity in three experiments [LOX (100 μM), APPH (51%), DPPH (36.5%)], being clearly more potent antioxidant agent than nitrone PBN. Consequently, we have identified (Z)-5-hydroxy-N-methyl-2,3-dihydro-1Hinden- 1-imine oxide (4) as a hit-molecule for further investigation.
Identifiersdoi: 10.1016/j.bioorg.2019.01.071
issn: 0045-2068
e-issn: 1090-2120
Appears in Collections:(IC) Artículos
(IQOG) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.