English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/19117
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Comparative physicochemical study of SIKVAV peptide and its retro and retro-enantio analogues

AuthorsAlmiñana, Nuria; Alsina, M. Asunción; Ortiz, A.; Reig Isart, Francesca
KeywordsSIKVAV
Retro and retro-enantio peptides
Surface activity
Compression isotherms
Kinetic penetration
Miscibility
Issue Date16-Nov-2004
PublisherElsevier
CitationColloids and Surfaces A: Physicochemical and Engineering Aspects 249 (1-3): 19-24 (2004)
AbstractSIKVAV is an active site of laminin involved in different physiological and pathological functions, including neurite outgrowth, angiogenesis and tumor development. In this paper, we report the synthesis of the retro (reverse L-amino acid order) and retro-enantio (reverse D-amino acid order) analogues of the SIKVAV peptide, in order to compare their physicochemical characteristics. When a linear peptide is synthesized with D-amino acids (enantio modification) assembled in the reverse order (retro modification), it presents side chains orientation very similar to that in the original structure. Such peptidomimetic approach provides peptides with a higher metabolic stability. However, there is no evidence if this peptidomimetic approach also maintains the physicochemical characteristics of the original sequence. Surface activity, compression isotherms, kinetic penetration into L-α-Dipalmitoylphosphatidylcholine and L-α-phosphatidylcholine monolayers and miscibility with L-α-Dipalmitoyl-phosphatidylcholine at different molar ratios were determined for each peptide. Results show that either retro or retro-enantio modifications enhance the hydrophilic character of the SIKVAV sequence.
Description6 pages, 6 figures, 1 table.-- Printed version published Nov 30, 2004.-- Issue title: "1st International Meeting on Applied Physics" (Badajoz, Spain, Oct 15-18, 2003).
Publisher version (URL)http://dx.doi.org/10.1016/j.colsurfa.2004.08.041
URIhttp://hdl.handle.net/10261/19117
DOI10.1016/j.colsurfa.2004.08.041
ISSN0927-7757
Appears in Collections:(IQAC) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.