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Diet effects on the gut microbiota and intestinal mucus proteome are linked to changes in the disease outcome due to the intestinal parasite Enteromyxum leei in gilthead sea bream (Sparus aurata)

AuthorsPiazzon de Haro, María Carla ; Calduch-Giner, Josep A. ; Simó Mirabet, Paula; Estensoro, Itziar ; Ortiz, A.; Karalazos, V.; Palenzuela, Oswaldo ; Fouz, B.; Sitjà-Bobadilla, Ariadna ; Pérez-Sánchez, Jaume
Issue Date21-Sep-2016
CitationAquaculture Europe (2016)
AbstractEnteromyxum leei is a widely spread myxozoan responsible for one of the most threatening parasitic diseases in Mediterranean fish cultures. This parasite invades the intestine of sea bream producing a slow-progressing disease, which induces anorexia, caquexia and may end in the death of fish. Its impact is further enhanced due to its direct fish-to-fish transmission either by cohabitation with infected fish or by contact with contaminated effluent. Thus far, there are neither preventive nor curative treatments for enteromyxosis, and there is an urgent need in advancing in the knowledge of the parasite itself and the hostparasite interaction. This is reinforced by the observation that the progression of the infection and the severity of the disease signs were higher in fish fed vegetable oils (Estensoro et. al., 2011), with a clear destruction of the intestinal epithelia as evidenced by histology and microarray gene expression profiling of parasite-exposed fish (Calduch-Giner et al., 2012). In the ARRAINA project we have shown that this nutritionally-mediated effect is linked to a pro-inflammatory condition in fish fed the extremely low FM/FO diet, which was mostly reversed by butyrate supplementation. The hypothesis of work is that these nutritionally-mediated changes can be extensive to intestinal mucus proteome and gut microbiota, which in turn could modify the disease outcome. If so, the prevalence and progression of the disease might be also modified by diet composition and feed additives.
DescriptionTrabajo presentado en Aquaculture Europe 2016: Food for Thought, celebrado en Edimburgo (Escocia) del 21 al 23 de septiembre de 2016
Appears in Collections:(IATS) Comunicaciones congresos
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