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Title

Interaction of three β-interferon domains with liposomes and monolayers as model membranes

AuthorsLarios, Cristina; Espina, Marta; Alsina, M. Asunción ; Haro Villar, Isabel
Keywordsβ-Interferon
Synthetic peptides
Phospholipids
Monolayers
Liposomes
Differential scanning calorimetry
Issue Date9-Jun-2004
PublisherElsevier
CitationBiophysical Chemistry 111(2): 123-133 (2004)
AbstractThe physicochemical properties of three peptides belonging to the β-interferon (β-IFN) molecule, -β-IFN(13–20), β-IFN(40–47) and β-IFN(109–116)-, which have been described to be antigenic epitopes of the neutralising antibodies responsible of the failure of the Multiple Sclerosis therapy, and their palmitoylated derivatives were analysed. Peptides were synthesised by solid-phase methodologies and characterized by amino acid analysis, analytical high-performance liquid chromatography and electrospray mass spectrometry. The activity of free and derivatized peptides was determined. In order to know how the synthesised peptides were able to interact with membrane models, studies of kinetics of penetration at constant area and compression isotherms were carried out. Moreover, differential scanning calorimetry (DSC) was used to investigate the thermotropic phase properties of binary mixtures of dipalmitoylphosphatidylcholine (DPPC) or dipalmitoylphosphatidylglicerol (DPPG) with the peptides.
Description11 pages, 7 figures, 4 tables.-- PMID: 15381310 [PubMed].-- Printed version published Oct 1, 2004.
Publisher version (URL)http://dx.doi.org/10.1016/j.bpc.2004.05.004
URIhttp://hdl.handle.net/10261/19104
DOI10.1016/j.bpc.2004.05.004
ISSN0301-4622
E-ISSN1873-4200
Appears in Collections:(IQAC) Artículos
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