Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/190695
Share/Export:
![]() ![]() |
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Title: | Nanocarbon-based glycoconjugates as multivalent inhibitors of ebola virus infection |
Authors: | Rodríguez-Pérez, Laura; Ramos-Soriano, Javier; Pérez-Sánchez, Alfonso; Illescas, Beatriz M.; Muñoz, Antonio; Luczkowiak, Joanna; Lasala, Fátima; Rojo, Francisco Javier ; Delgado, Rafael; Martín, Nazario | Issue Date: | 8-Aug-2018 | Publisher: | American Chemical Society | Citation: | Journal of the American Chemical Society 140(31): 9891-9898 (2018) | Abstract: | SWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC >click chemistry> approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection. | Publisher version (URL): | https://doi.org/10.1021/jacs.8b03847 | URI: | http://hdl.handle.net/10261/190695 | DOI: | 10.1021/jacs.8b03847 | ISSN: | 0002-7863 | E-ISSN: | 1520-5126 |
Appears in Collections: | (IIQ) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
ms jacs_030618.docx | 7,43 MB | Microsoft Word XML | View/Open |
Review this work
SCOPUSTM
Citations
42
checked on May 16, 2022
WEB OF SCIENCETM
Citations
36
checked on May 21, 2022
Page view(s)
270
checked on May 23, 2022
Download(s)
113
checked on May 23, 2022
Google ScholarTM
Check
Altmetric
Dimensions
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.