Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/19066
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Mitjans, Montserrat | - |
dc.contributor.author | Campo, Jaime del | - |
dc.contributor.author | Abajo, Celia | - |
dc.contributor.author | Martínez, Verónica | - |
dc.contributor.author | Selga, Ariadna | - |
dc.contributor.author | Lozano, Carles | - |
dc.contributor.author | Torres, Josep Lluís | - |
dc.contributor.author | Vinardell, M. Pilar | - |
dc.date.accessioned | 2009-11-26T11:58:49Z | - |
dc.date.available | 2009-11-26T11:58:49Z | - |
dc.date.issued | 2004-10-28 | - |
dc.identifier.citation | Journal of Agricultural and Food Chemistry 52(24): 7297-7299 (2004) | en_US |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | http://hdl.handle.net/10261/19066 | - |
dc.description | 3 pages, 3 fgures, 1 tables.-- PMID: 15563210 [PubMed].-- Printed version published Dec 1, 2004. | en_US |
dc.description.abstract | We examined the potential antioxidant activity and the immunopharmacological activity of new epicatechin conjugates obtained by depolymerization of grape polymeric flavanols in the presence of cysteamine or cysteine and with or without gallate. The compounds studied were (−)-epicatechin (1), cysteinyl-epicatechin (2), cysteamine-epicatechin (3), (−)-epicatechin gallate (4), cysteinyl-epicatechin gallate (5), and cysteamine-epicatechin gallate (6) When incubated with an erythrocyte suspension, flavanols protected the erythrocyte membrane from hemolysis induced by 2,2‘-azobis(2-amidinopropane) dihydrochloride, an azo free-radical initiator. All the epicatechin derivatives tested were more efficient as antioxidant than epicatechin. The most potent antioxidant was compound 6. The compounds were tested for their capacity to modulate IL-1β and IL-6, which are the main cytokine factors influencing the acute phase of the inflammatory response. (−)-Epicatechin and its related compounds inhibited the production of IL-1β and IL-6 in whole blood incubated in the presence of Escherichia coli lipopolysaccharide. The most efficient inhibitor of cytokine formation was compound. | en_US |
dc.description.sponsorship | This work was supported by grants PTR1995-061-OP and PPQ2003-06602- C04-01 from Ministerio de Ciencia y Tecnología, Spain. | en_US |
dc.format.extent | 22195 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | closedAccess | en_US |
dc.subject | Antioxidants | en_US |
dc.subject | Grape | en_US |
dc.subject | Polyphenols | en_US |
dc.subject | Immunomodulatory activity | en_US |
dc.subject | Red blood cells | en_US |
dc.title | Immunomodulatory activity of a new family of antioxidants obtained from grape polyphenols | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1021/jf049403z | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1021/jf049403z | en_US |
dc.identifier.e-issn | 1520-5118 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IQAC) Artículos |
CORE Recommender
SCOPUSTM
Citations
30
checked on 18-abr-2024
WEB OF SCIENCETM
Citations
23
checked on 29-feb-2024
Page view(s)
371
checked on 21-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.