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Immunomodulatory activity of a new family of antioxidants obtained from grape polyphenols

AuthorsMitjans, Montserrat; Campo, Jaime del; Abajo, Celia; Martínez, Verónica; Selga, Ariadna; Lozano, Carles; Torres, Josep Lluís ; Vinardell, M. Pilar
Immunomodulatory activity
Red blood cells
Issue Date28-Oct-2004
PublisherAmerican Chemical Society
CitationJournal of Agricultural and Food Chemistry 52(24): 7297-7299 (2004)
AbstractWe examined the potential antioxidant activity and the immunopharmacological activity of new epicatechin conjugates obtained by depolymerization of grape polymeric flavanols in the presence of cysteamine or cysteine and with or without gallate. The compounds studied were (−)-epicatechin (1), cysteinyl-epicatechin (2), cysteamine-epicatechin (3), (−)-epicatechin gallate (4), cysteinyl-epicatechin gallate (5), and cysteamine-epicatechin gallate (6) When incubated with an erythrocyte suspension, flavanols protected the erythrocyte membrane from hemolysis induced by 2,2‘-azobis(2-amidinopropane) dihydrochloride, an azo free-radical initiator. All the epicatechin derivatives tested were more efficient as antioxidant than epicatechin. The most potent antioxidant was compound 6. The compounds were tested for their capacity to modulate IL-1β and IL-6, which are the main cytokine factors influencing the acute phase of the inflammatory response. (−)-Epicatechin and its related compounds inhibited the production of IL-1β and IL-6 in whole blood incubated in the presence of Escherichia coli lipopolysaccharide. The most efficient inhibitor of cytokine formation was compound.
Description3 pages, 3 fgures, 1 tables.-- PMID: 15563210 [PubMed].-- Printed version published Dec 1, 2004.
Publisher version (URL)http://dx.doi.org/10.1021/jf049403z
Appears in Collections:(IQAC) Artículos
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