English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/190450
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Unsaponifiable and phenolic fractions from virgin olive oil prevent neuroinflammation skewing microglia polarization toward M2 phenotype

AuthorsToscano, Rocío; Millán-Linares, María del Carmen ; Naranjo, María C.; Lemus-Conejo, Ana; Claro, Carmen; Montserrat-de la Paz, Sergio
KeywordsOlive oil
Phenols
Unsaponifiable
Microglia
Neuroinflammation
Issue DateNov-2019
PublisherElsevier
CitationJournal of Functional Foods 62: 103543 (2019)
AbstractInhibiting M1 microglia phenotype while stimulating M2 microglia phenotype has been suggested as potential therapeutic approach for the treatment of neuroinflammation-related diseases. Our aim was to evaluate the anti-neuroinflammatory effects of minor compounds found in unsaponifiable fraction (UF) and in phenolic fraction (PF) of virgin olive oil (VOO) in BV-2 microglial cells and in brain of mice with high-fat diet (HFD)-induced obesity by RT-qPCR, ELISA and flow cytometry techniques. We observed that UF and PF enhance M2 microglia polarization, whereas LPS polarized microglia prone to M1 phenotype. In addition, in contrast to dietary SFAs, dietary VOO primed for a reduced pro-inflammatory profile in the brain of mice. These findings unveil a potential beneficial role for minor compounds of VOO in regulating the plasticity of microglia. These exciting findings open opportunities for developing nutraceutical strategies with olive oil as principal source of fat to prevent development and progression of neuroinflammation-related diseases.
Description39 Páginas.-- 5 Figuras.-- 4 Tablas
Publisher version (URL)http://dx.doi.org/10.1016/j.jff.2019.103543
URIhttp://hdl.handle.net/10261/190450
ISSN1756-4646
E-ISSN2214-9414
Appears in Collections:(IG) Artículos
Files in This Item:
File Description SizeFormat 
PostP_2019_JFunctFoods_V62_103543.pdf Embargoed until November 1, 2020Artículo principal2,07 MBAdobe PDFThumbnail
View/Open    Request a copy
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.