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Título: | Pectin-rich extracts from olives inhibit proliferation of Caco-2 and THP-1 cells |
Autor: | Bermúdez-Oria, Alejandra CSIC ORCID; Rodríguez-Gutiérrez, Guillermo CSIC ORCID ; Alaíz Barragán, Manuel CSIC ORCID ; Vioque, Javier CSIC ORCID ; Girón-Calle, Julio CSIC ORCID ; Fernández-Bolaños Guzmán, Juan CSIC ORCID | Fecha de publicación: | 15-jul-2019 | Editor: | Royal Society of Chemistry (UK) | Citación: | Food and Function 10: 4844-4853 (2019) | Resumen: | Three olive modified pectin extracts have been produced by heat and acid treatment of the major by-product of olive oil production. Their effect on proliferation of the colon carcinoma Caco-2 and the leukemia monocytic THP-1 cell lines has been studied in order to determine possible anti-tumor properties. All extracts inhibited proliferation at some of the concentrations ranging from 1 to 10 mg ml−1. Interestingly none of the extracts inhibited the growth of confluent Caco-2 cells, showing the specificity of the antiproliferative effect for the transformed Caco-2 phenotype. All the extracts inhibited agglutination of red blood cells by galectin-3, a lectin involved in tumor growth, metastasis, and immune cell regulation that has been proposed as a mediator of the anti-tumor effects of modified pectins. In addition, activation of caspase-3 in THP-1 cells indicates that treatment with the pectin-rich extracts triggers apoptosis. These results point to a possible use as health-promoting food ingredients or supplements. | Descripción: | 30 Páginas.-- 5 Figuras.-- 2 Tablas | Versión del editor: | http://dx.doi.org/10.1039/C9FO00917E | URI: | http://hdl.handle.net/10261/190363 | ISSN: | 2042-6496 | E-ISSN: | 2042-650X |
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