Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/190145
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Glucose uptake and glucose transporter proteins in skeletal muscle from undernourished rats |
Autor: | Agote, María; Goya, Luis CSIC ORCID; Ramos, Sonia CSIC ORCID ; Álvarez, Carmen; Gavete, M. Lucía; Pascual-Leone, Ana María; Escrivá, Fernando | Palabras clave: | Undernutrition Insulin signaling Muscle glucose transporters |
Fecha de publicación: | 2001 | Editor: | American Physiological Society | Citación: | AJP - Endocrinology and Metabolism 281(5): E1101-E1109 (2001) | Resumen: | Undernutrition in rats impairs secretion of insulin but maintains glucose normotolerance, because muscle tissue presents an increased insulin-induced glucose uptake. We studied glucose transporters in gastrocnemius muscles from food-restricted and control anesthetized rats under basal and euglycemic hyperinsulinemic conditions. Muscle membranes were prepared by subcellular fractionation in sucrose gradients. Insulin-induced glucose uptake, estimated by a 2-deoxyglucose technique, was increased 4- and 12-fold in control and food-restricted rats, respectively. Muscle insulin receptor was increased, but phosphotyrosine-associated phosphatidylinositol 3-kinase activity stimulated by insulin was lower in undernourished rats, whereas insulin receptor substrate-1 content remained unaltered. The main glucose transporter in the muscle, GLUT-4, was severely reduced albeit more efficiently translocated in response to insulin in food-deprived rats. GLUT-1, GLUT-3, and GLUT-5, minor isoforms in skeletal muscle, were found increased in food-deprived rats. The rise in these minor glucose carriers, as well as the improvement in GLUT-4 recruitment, is probably insufficient to account for the insulin-induced increase in the uptake of glucose in undernourished rats, thereby suggesting possible changes in other steps required for glucose metabolism. | Versión del editor: | https://doi.org/10.1152/ajpendo.2001.281.5.E1101 | URI: | http://hdl.handle.net/10261/190145 | DOI: | 10.1152/ajpendo.2001.281.5.E1101 | ISSN: | 0193-1849 | E-ISSN: | 1522-1555 |
Aparece en las colecciones: | (ICTAN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 59,24 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
7
checked on 10-abr-2024
SCOPUSTM
Citations
25
checked on 17-abr-2024
WEB OF SCIENCETM
Citations
25
checked on 23-feb-2024
Page view(s)
188
checked on 19-abr-2024
Download(s)
24
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.