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Synthesis, in vitro profiling, and in vivo efficacy studies of a new family of multitarget anti-alzheimer compounds

AuthorsPérez-Areales, Francisco Javier; Garrido, María; Aso, Ester; Bartolini, Manuela; Simone, Angela; Espargaró, Alba; Ginex, Tiziana ; Sabate, Raimon; Pérez, Belén ; Andrisano, Vincenza; Luque, Francisco Javier; Ferrer, Isidro; Ciruela, Francisco; Messeguer Peypoch, Ángel ; Muñoz-Torrero, Diego
KeywordsMultitarget compounds
Multitarget-directed ligands
Acetylcholinesterase inhibitors
Butyrylcholinesterase inhibitors
BACE-1 inhibitors, anti-aggregating agents
Antioxidant properties
Brain permeability
In vivo efficacy studies
Issue Date14-Aug-2019
PublisherMultidisciplinary Digital Publishing Institute
CitationProceedings 22(1): 71 (2019)
AbstractSimultaneous modulation of several targets or pathological events with a key pathogenic role is a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases, such as Alzheimer’s disease (AD). In this scenario, multitarget compounds, i.e., single molecules that hit several targets, are superior to other multitarget strategies that are based on the use of more than one drug (drug cocktails, fixed-dose combinations), in terms of simpler drug development and better patient compliance, efficiency, and safety.
Publisher version (URL)https://doi.org/10.3390/proceedings2019022071
Appears in Collections:(IQAC) Artículos
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