English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/189734
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorAttia, Nohaes_ES
dc.contributor.authorMashal, Mohamedes_ES
dc.contributor.authorGrijalvo, Santiagoes_ES
dc.contributor.authorEritja Casadellà, Ramónes_ES
dc.contributor.authorPuras, Gustavoes_ES
dc.contributor.authorPedraz, José Luíses_ES
dc.date.accessioned2019-09-03T08:22:23Z-
dc.date.available2019-09-03T08:22:23Z-
dc.date.issued2019-10-
dc.identifier.citationJournal of Drug Delivery Science and Technology 53: 101219 (2019)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/189734-
dc.description.abstractThis study explores interesting complementary approaches in cell-based hBMP7 gene delivery in order to mitigate the migration of glioblastoma cells based on the idea that this human bone morphogenetic protein (hBMP7) has enormous therapeutic potential in curing brain injuries as well as malignancies. After physicochemical characterization, the non-viral cationic niosomes were complexed with pUNO1-hBMP7 plasmids and used to transfect neuronal precursor NT2 cells. Subsequently, the transfected cells were co-cultured with glioma C6 cells to determine their antitumor effect in vitro. However the co-culture with either untransfected/transfected NT2 cells may reduce the viability of C6 glioma cells, the hBMP7-overexpressing NT2 cells hamper the migration of C6 glioma cells. These results highlight the potential of NT2 cell-based delivery of hBMP7 for impeding the metastasis of glioma cells. © 2019 Elsevier B.V.es_ES
dc.description.sponsorshipThis project was supported by the Basque Country Government (CGIC10/172), The Spanish Ministry of Education (Grant CTQ2014-52588-R), the Generalitat de Catalunya (2014/SGR/624) and the Instituto de Salud Carlos III (CB06_01_0019, CB06_01_1028).The authors also wish to thank the intellectual and technical assistance from the ICTS “NANBIOSIS”, more specifically by the Drug Formulation Unit (U10) of the CIBER at Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN) at the University of Basque Country (UPV/EHU). Technical and human support provided by SGIker (UPV/EHU) is gratefully acknowledged.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccessen_EN
dc.subjectGene therapyes_ES
dc.subjectNiosomeses_ES
dc.subjectGlioblastomaes_ES
dc.subjecthBMP7es_ES
dc.subjectNT2 cellses_ES
dc.titleCationic niosome-based hBMP7 gene transfection of neuronal precursor NT2 cells to reduce the migration of glioma cells in vitroes_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.1016/j.jddst.2019.101219-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.jddst.2019.101219es_ES
dc.embargo.terms2020-10-01es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.contributor.orcidEritja Casadellà, Ramón [0000-0001-5383-9334]es_ES
Appears in Collections:(IQAC) Artículos
Files in This Item:
File Description SizeFormat 
Cationic niosome-based hBMP7 gene transfection of.pdfArtículo principal863,18 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.