English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/189411
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


PGC-1α downregulation in steatotic liver enhances ischemia-reperfusion injury and impairs ischemic preconditioning

AuthorsSánchez-Ramos, Cristina; Prieto, Ignacio; Tierrez, Albert; Laso, Javier; Valdecantos, M. P.; Bartrons, Ramón; Roselló-Catafau, Joan ; Monsalve, María
Oxidative metabolism
Reactive oxygen species
Oxidative stress
Issue Date2017
CitationOCC World Congress and Annual SFRR-E Conference (2017)
AbstractLiver steatosis is associated with mitochondrial dysfunction and elevated Reactive Oxygen Species (ROS) levels together with enhanced sensitivity to IR injury and limited response to preconditioning protocols. Here, we sought to determine whether the downregulation in the steatotic liver of PGC-1a, a master regulator of mitochondrial metabolism and ROSl, could be responsible for the sensitivity of steatotic liver to ischemic damage. PGC-1a was induced in normal liver following exposure to an IR protocol concomitant with an increase in the levels of antioxidant proteins. By contrast, its induction was severely blunted in steatotic liver, resulting in a modest induction of antioxidant proteins. Livers of PGC-1a-/- mice on chow diet were normal, but they exhibited an enhanced sensitivity to IR injury and also a lack of response to ischemic preconditioning, a phenotype that recapitulated the features of steatotic liver in terms of liver damage. Utilizing an in vitro model of IPC, we found that PGC-1a expression was downregulated in hepatic cells cultured at 1% O2 whereas it was induced following reoxygenation (3% O2), and was responsible for the recovery of antioxidant gene expression following the ischemic period. We concluded that PGC-1a plays an important role in the protection against IR injury in the liver, which is likely associated with its capacity to induce antioxidant gene expression.
DescriptionResumen del póster presentado al OCC World Congress and Annual SFRR-E Conference: "Metabolic Stress and Redox Regulation", celebrados en Berlin (Alemania) del 21 la 23 de junio de 2017.
Appears in Collections:(IIBM) Comunicaciones congresos
(IIBB) Comunicaciones congresos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.