English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/189362
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

AuthorsFerretti, Pamela; Pasolli, Edoardo; Tett, Adrian; Asnicar, Francesco; Gorfer, Valentina; Fedi, Sabina; Armanini, Federica; Truong, Duy Tin; Manara, Serena; Zolfo, Moreno; Beghini, Francesco; Bertorelli, Roberto; de Sanctis, Veronica; Bariletti, Ilaria; Canto, Rosarita; Clementi,Rosanna; Cologna,Marina; Crifò, Tiziana; Cusumano, Giuseppina; Gottardi, Stefania; Innamorati, Claudia; Masè,Caterina; Postai,Daniela; Savoi, Daniela; Duranti, Sabrina; Lugli,Gabriele Andrea; Mancabelli, Leonardo; Turroni, Francesca; Ferrario, Chiara; Milani, Christian; Mangifesta, Marta; Anzalone, Rosaria; Viappiani, Alice; Yassour, Moran; Vlamakis, Hera; Xavier, Ramnik; Collado, María Carmen ; Koren,Omry; Tateo, Saverio; Soffiati,Massimo; Pedrotti, Anna; Ventura, Marco; Huttenhower, Curtis; Bork, Peer; Segata, Nicola
KeywordsInfant microbiome
Shotgun metagenomics
Strain-level profiling
Microbiome transmission
Issue Date11-Jul-2018
PublisherCell Press
CitationCell Host and Microbe 24 (1): 133-145.e5 (2018)
AbstractThe acquisition and development of the infant microbiome are key to establishing a healthy host-microbiome symbiosis. The maternal microbial reservoir is thought to play a crucial role in this process. However, the source and transmission routes of the infant pioneering microbes are poorly understood. To address this, we longitudinally sampled the microbiome of 25 mother-infant pairs across multiple body sites from birth up to 4 months postpartum. Strain-level metagenomic profiling showed a rapid influx of microbes at birth followed by strong selection during the first few days of life. Maternal skin and vaginal strains colonize only transiently, and the infant continues to acquire microbes from distinct maternal sources after birth. Maternal gut strains proved more persistent in the infant gut and ecologically better adapted than those acquired from other sources. Together, these data describe the mother-to-infant microbiome transmission routes that are integral in the development of the infant microbiome.
URIhttp://hdl.handle.net/10261/189362
DOI10.1016/j.chom.2018.06.005
ISSN1931-3128
Appears in Collections:(IATA) Artículos
Files in This Item:
File Description SizeFormat 
CHM2018-Ferretti.pdfArtículo principal2,96 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.