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Título: | Cyclooxygenase-2 expression in hepatocytes protects against liver fibrosis in mice through the regulation of miRNA23a-5p |
Autor: | Motiño, Omar CSIC ORCID CVN; Brea, Rocío CSIC; García-Monzón, Carmelo; Vargas, Javier; Boscá, Lisardo CSIC ORCID CVN ; Francés, Daniel E.; Casado, Marta CSIC ORCID ; Martín-Sanz, Paloma CSIC ORCID ; Agra, Noelia CSIC | Fecha de publicación: | 2017 | Citación: | EMBO Workshop (2017) | Resumen: | Cyclooxygenase-2 (COX-2) is involved in different liver diseases but little is known about the significance of COX-2 in the development and progression of fibrosis. In the present work, hepatocytespecific COX-2 transgenic mice (hCOX-2-Tg) and their wild-type (Wt) littermates were injected with carbon tetrachloride (CC14) for 9 weeks or subjected to bile duct ligation (BDL) for 21 days to induce liver fibrosis. Different cells types were isolated analyzing the expression of a specific set of rniRNAs implicated in liver fibrosis. Furthermore, considering COX-2 expression in hepatocytes could protect against fibrosis by modulating the activation of hepatic stellate cells (HSC), we evaluated the effect of conditioned medium from isolated hepatocytes of COX-2 in primary HSC cells. Our results provide evidence that COX-2-dependent PGs protects against fibrosis by decreasing the Jevels of pro-fibrogenic markers a-SMA and collagen l a l and increasing apoptosis of HSC. Furthermore, the constitutive expression of COX-2 in hepatocytes represses rniRNA-23a-5p expression in HSC cells. These results suggest a protective effect exerted by COX-2 in the process of liver fibrosis, possibly through the downregulation of rniR-23a-5p. Further work is in progress to clarify the role of this miRNA and to identify putative target genes. | Descripción: | Resumen del trabajo presentado al EMBO Workshop: "Metabolic disorders and liver cancer", celebrado en Palma de Mallorca (España) del 23 al 26 de abril de 2017. | URI: | http://hdl.handle.net/10261/189344 |
Aparece en las colecciones: | (IIBM) Comunicaciones congresos |
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