English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/188960
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer’s Disease Patients

AuthorsCosín-Tomás, Marta; Senserrich, Júlia; Arumí-Planas, Marta; Alquézar, Carolina ; Pallàs, Mercè; Martín-Requero, Ángeles ; Suñol, Cristina ; Kaliman, Perla ; Sanfeliu, Coral
KeywordsAlzheimer’s disease
Immortalized B lymphoblastoid cell lines
Oxidative stress
Gene expression
Issue Date31-Jul-2019
PublisherMultidisciplinary Digital Publishing Institute
CitationNutrients 11(8): 1764 (2019)
AbstractOxidative damage is involved in the pathophysiology of age-related ailments, including Alzheimer’s disease (AD). Studies have shown that the brain tissue and also lymphocytes from AD patients present increased oxidative stress compared to healthy controls (HCs). Here, we use lymphoblastoid cell lines (LCLs) from AD patients and HCs to investigate the role of resveratrol (RV) and selenium (Se) in the reduction of reactive oxygen species (ROS) generated after an oxidative injury. We also studied whether these compounds elicited expression changes in genes involved in the antioxidant cell response and other aging-related mechanisms. AD LCLs showed higher ROS levels than those from HCs in response to H2O2 and FeSO4 oxidative insults. RV triggered a protective response against ROS under control and oxidizing conditions, whereas Se exerted antioxidant effects only in AD LCLs under oxidizing conditions. RV increased the expression of genes encoding known antioxidants (catalase, copper chaperone for superoxide dismutase 1, glutathione S-transferase zeta 1) and anti-aging factors (sirtuin 1 and sirtuin 3) in both AD and HC LCLs. Our findings support RV as a candidate for inducing resilience and protection against AD, and reinforce the value of LCLs as a feasible peripheral cell model for understanding the protective mechanisms of nutraceuticals against oxidative stress in aging and AD.
Publisher version (URL)https://doi.org/10.3390/nu11081764
Appears in Collections:(CIB) Artículos
(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
role_resveratrol_selenium_oxidative_stress _expression.pdf2,87 MBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.