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Título: | Impact of dietary lipoic acid supplementation on liver mitochondrial bioenergetics and oxidative status on normally fed Wistar rats |
Autor: | Valdecantos, M. P. CSIC ORCID; Pérez-Matute, Patricia; Prieto-Hontoria, P.; Moreno-Aliaga, María Jesús; Martínez, J. A. | Palabras clave: | Lipoic acid Healthy rats Isocaloric standard chow diet Liver Mitochondria Oxidative stress |
Fecha de publicación: | 2019 | Editor: | Taylor & Francis | Citación: | International Journal of Food Sciences and Nutrition 15: 1-11 (2019) | Resumen: | The aim of this study was to examine the effects of α-lipoic acid (α-LA) on liver mitochondrial bioenergetics and oxidative status for 8 weeks in normal-healthy animals. A pair-fed group was included to differentiate between α-LA direct effects and those changes due to reduced food intake. α-LA decreased body weight gain, liver weight and insulin levels with no differences compared to its pair-fed group. α-LA significantly reduced energy efficiency, the activity of the electron transport chain complexes and induced a lower efficiency of oxidative phosphorylation with reduced ATP production. α-LA supplementation directly decreased plasma triglycerides (TGs), free fatty acids and ketone bodies levels. A significant reduction in hepatic TG content was also observed. A significant up-regulation of Cpt1a, Acadl and Sirt3, all β-oxidation genes, along with a significant deacetylation of the forkhead transcription factor 3a (FOXO3A) was found in α-LA-treated animals. Thus, α-LA along with a standard chow diet has direct actions on lipid metabolism and liver by modulating mitochondrial function in normal-weight rats. These results should be taken into account when α-LA is administered or recommended to a healthy population. | Versión del editor: | https://doi.org/10.1080/09637486.2019.1572716 | URI: | http://hdl.handle.net/10261/188804 | DOI: | 10.1080/09637486.2019.1572716 | ISSN: | 0963-7486 | E-ISSN: | 1465-3478 |
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