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dc.contributor.authorMachado, Noelia D.-
dc.contributor.authorFernández, Mariana A.-
dc.contributor.authorHäring, Marleen-
dc.contributor.authorSaldías, César-
dc.contributor.authorDíaz Díaz, David-
dc.date.accessioned2019-08-20T08:38:03Z-
dc.date.available2019-08-20T08:38:03Z-
dc.date.issued2019-03-08-
dc.identifierdoi: 10.1039/C8RA09655D-
dc.identifierissn: 2046-2069-
dc.identifier.citationRSC Advances 9: 7601-7609 (2019)-
dc.identifier.urihttp://hdl.handle.net/10261/188556-
dc.description.abstractA series of biohydrogels based on mixtures of kappa-carrageenan (κ-carrageenan, κ-C) and gelatin were evaluated as potential soft delivery vehicles for the encapsulation and subsequent release of non-ionic surfactant vesicles (niosomes) loaded with resveratrol (RSV). The niosomes were prepared using a mixture of amphiphilic lipids Tween 80 and Span 80 in water. The results showed that RSV-niosomes did not significantly affect the hydrogelation properties of the biopolymer mixture. Moreover, in vitro drug release experiments from biohydrogels containing RSV-niosomes were successfully carried out under simulated gastrointestinal conditions. The RSV-niosomal liberation profiles from hydrogels were fitted using first order kinetics, Higuchi, Korsmeyer-Peppas and Weibull drug release models, showing the prevalence of diffusion mechanisms in each case. In addition, the RSV release was easily tuned by adjusting the total concentration of κ-C : gelatin. Interestingly, the niosomal-hydrogel system was also found to prevent the trans-to-cis photoisomerization of RSV.-
dc.description.sponsorshipWe thank the University of Regensburg and the Deutsche Forschungsgemeinschaft (DFG) (DI 1748/3-1) for financial support and CONICET (PIP 112-2015-01-00242) and Agencia Nacional de Ciencia y Tecnología, Argentina (PICT 2014-2516) for financial support. N. D. M. thanks Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, Argentina) for a fellowship, and the International PhD program at the University of Regensburg (iPUR) for granting a research internship. M. A. F. hold a researcher position at CONICET.-
dc.publisherRoyal Society of Chemistry (UK)-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.subjectNiosomes encapsulated-
dc.subjectResveratrol-
dc.subjectPhytoalexin-
dc.subjectBiohydrogels-
dc.titleNiosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol-
dc.typeartículo-
dc.relation.publisherversionhttp://xlink.rsc.org/?DOI=c8ra09655d-
dc.date.updated2019-08-20T08:38:03Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderConsejo Nacional de Investigaciones Científicas y Técnicas (Argentina)-
dc.contributor.funderAgencia Nacional de Promoción Científica y Tecnológica (Argentina)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003074es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002923es_ES
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