Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/188556
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol |
Autor: | Machado, Noelia D.; Fernández, Mariana A.; Häring, Marleen; Saldías, César; Díaz Díaz, David CSIC ORCID | Palabras clave: | Niosomes encapsulated Resveratrol Phytoalexin Biohydrogels |
Fecha de publicación: | 8-mar-2019 | Editor: | Royal Society of Chemistry (UK) | Citación: | RSC Advances 9: 7601-7609 (2019) | Resumen: | A series of biohydrogels based on mixtures of kappa-carrageenan (κ-carrageenan, κ-C) and gelatin were evaluated as potential soft delivery vehicles for the encapsulation and subsequent release of non-ionic surfactant vesicles (niosomes) loaded with resveratrol (RSV). The niosomes were prepared using a mixture of amphiphilic lipids Tween 80 and Span 80 in water. The results showed that RSV-niosomes did not significantly affect the hydrogelation properties of the biopolymer mixture. Moreover, in vitro drug release experiments from biohydrogels containing RSV-niosomes were successfully carried out under simulated gastrointestinal conditions. The RSV-niosomal liberation profiles from hydrogels were fitted using first order kinetics, Higuchi, Korsmeyer-Peppas and Weibull drug release models, showing the prevalence of diffusion mechanisms in each case. In addition, the RSV release was easily tuned by adjusting the total concentration of κ-C : gelatin. Interestingly, the niosomal-hydrogel system was also found to prevent the trans-to-cis photoisomerization of RSV. | Versión del editor: | http://xlink.rsc.org/?DOI=c8ra09655d | URI: | http://hdl.handle.net/10261/188556 | DOI: | 10.1039/C8RA09655D | Identificadores: | doi: 10.1039/C8RA09655D issn: 2046-2069 |
Aparece en las colecciones: | (IPNA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Niosomes_encapsulated_DDiaz_RSCAd19.pdf | 733,76 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
24
checked on 10-abr-2024
WEB OF SCIENCETM
Citations
17
checked on 23-feb-2024
Page view(s)
236
checked on 22-abr-2024
Download(s)
216
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons