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Title

Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol

AuthorsMachado, Noelia D.; Fernández, Mariana A.; Häring, Marleen; Saldías, César; Díaz Díaz, David
KeywordsNiosomes encapsulated
Resveratrol
Phytoalexin
Biohydrogels
Issue Date8-Mar-2019
PublisherRoyal Society of Chemistry (UK)
CitationRSC Advances 9: 7601-7609 (2019)
AbstractA series of biohydrogels based on mixtures of kappa-carrageenan (κ-carrageenan, κ-C) and gelatin were evaluated as potential soft delivery vehicles for the encapsulation and subsequent release of non-ionic surfactant vesicles (niosomes) loaded with resveratrol (RSV). The niosomes were prepared using a mixture of amphiphilic lipids Tween 80 and Span 80 in water. The results showed that RSV-niosomes did not significantly affect the hydrogelation properties of the biopolymer mixture. Moreover, in vitro drug release experiments from biohydrogels containing RSV-niosomes were successfully carried out under simulated gastrointestinal conditions. The RSV-niosomal liberation profiles from hydrogels were fitted using first order kinetics, Higuchi, Korsmeyer-Peppas and Weibull drug release models, showing the prevalence of diffusion mechanisms in each case. In addition, the RSV release was easily tuned by adjusting the total concentration of κ-C : gelatin. Interestingly, the niosomal-hydrogel system was also found to prevent the trans-to-cis photoisomerization of RSV.
Publisher version (URL)http://xlink.rsc.org/?DOI=c8ra09655d
URIhttp://hdl.handle.net/10261/188556
Identifiersdoi: 10.1039/C8RA09655D
issn: 2046-2069
Appears in Collections:(IPNA) Artículos
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