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Title

The ever-evolving concept of the cancer stem cell in pancreatic cancer

AuthorsValle, Sandra; Martin-Hijano, Laura; Alcalá, Sonia; Alonso-Nocelo, Marta; Sainz, Bruno Jr.
KeywordsEMT
Autophagy
Cancer stem cells
Chemoresistance
Hybrid cancer cell
Metabolism
Metastasis
Plasticity
Issue Date2018
PublisherMultidisciplinary Digital Publishing Institute
CitationCancers 10(2): 33 (2018)
AbstractPancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is the 4th most frequent cause of cancer-related death worldwide, primarily due to the inherent chemoresistant nature and metastatic capacity of this tumor. The latter is believed to be mainly due to the existence of a subpopulation of highly plastic "stem"-like cells within the tumor, known as cancer stem cells (CSCs), which have been shown to have unique metabolic, autophagic, invasive, and chemoresistance properties that allow them to continuously self-renew and escape chemo-therapeutic elimination. As such, current treatments for the majority of PDAC patients are not effective and do not significantly impact overall patient survival (<7 months) as they do not affect the pancreatic CSC (PaCSC) population. In this context, it is important to highlight the need to better understand the characteristics of the PaCSC population in order to develop new therapies to target these cells. In this review, we will provide the latest updates and knowledge on the inherent characteristics of PaCSCs, particularly their unique biological properties including chemoresistance, epithelial to mesenchymal transition, plasticity, metabolism and autophagy.
DescriptionThis article belongs to the Special Issue Latest Development in Pancreatic Cancer.
Publisher version (URL)https://doi.org/10.3390/cancers10020033
URIhttp://hdl.handle.net/10261/188483
DOIhttp://dx.doi.org/10.3390/cancers10020033
E-ISSN2072-6694
Appears in Collections:(IIBM) Artículos
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