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Title

Oxygenation imaging by nuclear magnetic resonance methods

AuthorsZhou, Heling; Arias, Nuria; López-Larrubia, Pilar ; Mason, Ralph P.; Cerdán, Sebastián ; Pacheco-Torres, Jesús
KeywordsMRI
Oximetry
pO2
BOLD
Hypoxia
Perfluorocarbons
Issue Date2018
CitationPreclinical MRI: 297-313 (2018)
SeriesMethods in Molecular Biology 1718
AbstractOxygen monitoring is a topic of exhaustive research due to its central role in many biological processes, from energy metabolism to gene regulation. The ability to monitor in vivo the physiological distribution and the dynamics of oxygen from subcellular to macroscopic levels is a prerequisite to better understand the mechanisms associated with both normal and disease states (cancer, neurodegeneration, stroke, etc.). This chapter focuses on magnetic resonance imaging (MRI) based techniques to assess oxygenation in vivo. The first methodology uses injected fluorinated agents to provide quantitative pO2 measurements with high precision and suitable spatial and temporal resolution for many applications. The second method exploits changes in endogenous contrasts, i.e., deoxyhemoglobin and oxygen molecules through measurements of T2* and T1, in response to an intervention to qualitatively evaluate hypoxia and its potential modulation.
Publisher version (URL)https://doi.org/10.1007/978-1-4939-7531-0_18
URIhttp://hdl.handle.net/10261/188342
DOI10.1007/978-1-4939-7531-0_18
ISBN978-1-4939-7530-3
Appears in Collections:(IIBM) Libros y partes de libros
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