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Dynamic susceptibility contrast MRI in small animals

AuthorsLópez-Larrubia, Pilar
KeywordsPreclinical MRI
Brain perfusion
Dynamic susceptibility contrast
Bolus tracking
Cerebral blood flow
Cerebral blood volume
Mean transit time
Animal model
Issue Date2018
PublisherSpringer Nature
CitationPreclinical MRI: 41-57 (2018)
SeriesMethods in Molecular Biology 1718
AbstractThe use of magnetic resonance imaging (MRI) for studying the cerebral perfusion mechanisms is well proved and contrasted in the clinical and research setups. This methodology is a promising tool in assessing numerous brain diseases like intracranial tumors, neurodegeneration processes, mental disorders, injuries and so on. In the preclinical environment, perfusion MRI offers a powerful resource for characterizing pathological models and specially identifying biomarkers to monitor the illness and validate the efficacy of therapeutical approaches. This chapter presents the theoretical bases and experimental protocols of dynamic susceptibility contrast MRI acquisitions for developing perfusion MRI studies in small animals.
Publisher version (URL)https://doi.org/10.1007/978-1-4939-7531-0_3
Appears in Collections:(IIBM) Libros y partes de libros
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