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Differential distribution and enrichment of non-coding RNAs in exosomes from normal and Cancer-associated fibroblasts in colorectal cancer

AuthorsHerrera, Mercedes; Llorens, Carlos; Rodríguez, Marta; Herrera, Alberto; Ramos, Ricardo; Gil, Beatriz; Candia, Antonio; Larriba, María Jesús ; Garre, Pilar; Earl, Julie; Rodríguez-Garrote, Mercedes; Caldés, Trinidad; Bonilla, Félix; Carrato, Alfredo; García, Vanesa; Peña, Cristina
KeywordsColon cancer
Liquid biopsy
Next generation sequencing
Non-coding RNAs
Tumor microenvironment
Issue Date2018
PublisherSpringer Nature
BioMed Central
CitationMolecular Cancer 17(1): 114 (2018)
AbstractExosome production from cancer-associated fibroblasts seems to be an important driver of tumor progression. We report the first in-depth biotype characterization of ncRNAs, analyzed by Next Generation Sequencing and Bioinformatics, expressed in established primary human normal and cancer-associated fibroblasts (CAFs) from cancer and normal mucosa tissues from 9 colorectal cancer patients, and/or packaged in their derived exosomes. Differential representation and enrichment analyses based on these ncRNAs revealed a significant number of differences between the ncRNA content of exosomes and the expression patterns of the normal and cancer-associated fibroblast cells. ncRNA regulatory elements are specifically packaged in CAF-derived exosomes, supporting a specific cross-talk between CAFs and colon cancer cells and/or other stromal cells, mediated by exosomes. These sncRNAs are potential biomarkers present in cancer-associated fibroblast-derived exosomes, which should thereby contribute to developing new non-invasive diagnostic, prognostic and predictive methods for clinical applications in management of cancer patients.
Publisher version (URL)https://doi.org/10.1186/s12943-018-0863-4
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