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Src-family tyrosine kinases and the Ca2 + signal

AuthorsAnguita, Estefanía; Villalobo, Antonio
Issue Date2017
CitationBiochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864(6): 915-932 (2017)
AbstractIn this review, we shall describe the rich crosstalk between non-receptor Src-family kinases (SFKs) and the Ca2+ transient generated in activated cells by a variety of extracellular and intracellular stimuli, resulting in diverse signaling events. The exchange of information between SFKs and Ca2+ is reciprocal, as it flows in both directions. These kinases are main actors in pathways leading to the generation of the Ca2+ signal, and reciprocally, the Ca2+ signal modulates SFKs activity and functions. We will cover how SFKs participate in the generation of the cytosolic Ca2+ rise upon activation of a series of receptors and the mechanism of clearance of this Ca2+ signal. The role of SFKs modulating Ca2+-translocating channels participating in these events will be amply discussed. Finally, the role of the Ca2+ sensor protein calmodulin on the activity of c-Src, and potentially on other SFKs, will be outlined as well. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.
Publisher version (URL)https://doi.org/10.1016/j.bbamcr.2016.10.022
Appears in Collections:(IIBM) Artículos
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