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http://hdl.handle.net/10261/186456
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dc.contributor.author | De Santis, Silvia | es_ES |
dc.contributor.author | Bach, Patrick | es_ES |
dc.contributor.author | Pérez-Cervera, Laura | es_ES |
dc.contributor.author | Cosa-Linan, Alejandro | es_ES |
dc.contributor.author | Weil, Georg | es_ES |
dc.contributor.author | Vollstädt‐Klein, Sabine | es_ES |
dc.contributor.author | Hermann, Derik | es_ES |
dc.contributor.author | Kiefer, Falk | es_ES |
dc.contributor.author | Kirsch, Peter | es_ES |
dc.contributor.author | Ciccocioppo, Roberto | es_ES |
dc.contributor.author | Sommer, Wolfgang H. | es_ES |
dc.contributor.author | Canals, Santiago | es_ES |
dc.date.accessioned | 2019-07-22T07:45:10Z | - |
dc.date.available | 2019-07-22T07:45:10Z | - |
dc.date.issued | 2019-04-03 | - |
dc.identifier.citation | JAMA Psychiatry 76(7): 749-758 (2019) | es_ES |
dc.identifier.issn | 0098-7484 | - |
dc.identifier.uri | http://hdl.handle.net/10261/186456 | - |
dc.description.abstract | [Importance] Although the detrimental effects of alcohol on the brain are widely acknowledged, observed structural changes are highly heterogeneous, and diagnostic markers for characterizing alcohol-induced brain damage, especially in early abstinence, are lacking. This heterogeneity, likely contributed to by comorbidity factors in patients with alcohol use disorder (AUD), challenges a direct link of brain alterations to the pathophysiology of alcohol misuse. Translational studies in animal models may help bridge this causal gap. | es_ES |
dc.description.abstract | [Objective] To compare microstructural properties extracted using advanced diffusion tensor imaging (DTI) in the brains of patients with AUD and a well-controlled rat model of excessive alcohol consumption and monitor the progression of these properties during early abstinence. | es_ES |
dc.description.abstract | [Design, Setting, and Participants] This prospective observational study included 2 cohorts of hospitalized patients with AUD (n = 91) and Marchigian Sardinian alcohol-preferring (msP) rats (n = 27). In humans cross-sectional comparison were performed with control participants (healthy men [n = 36]) and longitudinal comparisons between different points after alcohol withdrawal. In rats, longitudinal comparisons were performed in alcohol-exposed (n = 27) and alcohol-naive msP rats (n = 9). Human data were collected from March 7, 2013, to August 3, 2016, and analyzed from June 14, 2017, to May 31, 2018; rat data were collected from January 15, 2017, to May 12, 2017, and analyzed from October 11, 2017, to May 28, 2018. | es_ES |
dc.description.abstract | [Main Outcomes and Measures] Fractional anisotropy and other DTI measures of white matter properties after long-term alcohol exposure and during early abstinence in both species and clinical and demographic variables and time of abstinence after discharge from hospital in patients. | es_ES |
dc.description.abstract | [Results] The analysis included 91 men with AUD (mean [SD] age, 46.1 [9.6] years) and 27 male rats in the AUD groups and 36 male controls (mean [SD] age, 41.7 [9.3] years) and 9 male control rats. Comparable DTI alterations were found between alcohol and control groups in both species, with a preferential involvement of the corpus callosum (fractional anisotropy Cohen d = −0.84 [P < .01] corrected in humans and Cohen d = −1.17 [P < .001] corrected in rats) and the fornix/fimbria (fractional anisotropy Cohen d = −0.92 [P < .001] corrected in humans and d = −1.24 [P < .001] corrected in rats). Changes in DTI were associated with preadmission consumption patterns in patients and progress in humans and rats during 6 weeks of abstinence. Mathematical modeling shows this process to be compatible with a sustained demyelination and/or a glial reaction. | es_ES |
dc.description.abstract | [Conclusions and Relevance] Using a translational DTI approach, comparable white matter alterations were found in patients with AUD and rats with long-term alcohol consumption. In humans and rats, a progression of DTI alterations into early abstinence (2-6 weeks) suggests an underlying process that evolves soon after cessation of alcohol use. | es_ES |
dc.description.sponsorship | This study was supported by grant 668863-SyBil-AA from the European Union’s Horizon 2020 research and innovation programme, grants FKZ 01EW1112-TRANSALC and PIM2010ERN-00679 from the ERA-Net NEURON program, grant SEV- 2017-0723 from the Spanish State Research Agency through the Severo Ochoa Program for Centres of Excellence in R&D, and Center grant SFB636 from the Deutsche Forschungsgemeinschaft. Further financial support was obtained from grant BFU2015-64380-C2-1-R from the Ministerio de Economía y Competitividad (MINECO) and FEDER funds (Dr Canals), Ministerio de Sanidad, Servicios Sociales e Igualdad grant 2017I065 (Dr Canals), Young Investigator Grant 25104 from the National Alliance for Research on Schizophrenia and Depression (Dr De Santis), and Marie Skłodowska-Curie Individual Fellowship 749506 from the European Research Council. | - |
dc.language.iso | eng | es_ES |
dc.publisher | American Medical Association | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/668863 | - |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SEV-2017-0723 | - |
dc.relation | SEV-2017-0723/AEI/10.13039/501100011033 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2015-64380-C2-1-R | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/749506 | - |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | en_EN |
dc.title | Microstructural white matter alterations in men with alcohol use disorder and rats with excessive alcohol consumption during early abstinence | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1001/jamapsychiatry.2019.0318 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1001/jamapsychiatry.2019.0318 | es_ES |
dc.identifier.e-issn | 1538-3598 | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Agencia Estatal de Investigación (España) | - |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Ministerio de Sanidad, Servicios Sociales e Igualdad (España) | - |
dc.contributor.funder | German Research Foundation | - |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003751 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100001659 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011033 | es_ES |
dc.identifier.pmid | 30942831 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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