Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/186159
Share/Export:
![]() ![]() |
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Title: | Fast synthesis and bioconjugation of 68Ga core-doped extremely small iron oxide nanoparticles for PET/MR imaging |
Authors: | Pellico, Juan; Ruiz-Cabello, Jesús; Saiz-Alía, Marina; Rosario, Gilberto del; Caja, Sergio; Montoya, María ; Fernández de Manuel, Laura; Morales, M. P. CSIC ORCID ; Gutiérrez, Lucía CSIC ORCID; Galiana, Beatriz CSIC ORCID; Enríquez, José Antonio; Herranz, Fernando CSIC ORCID CVN | Keywords: | Iron Oxide T1‐MRI Nano‐radiotracer PET/MRI Chelator‐free 68Ga |
Issue Date: | 2-Jun-2016 | Publisher: | John Wiley & Sons | Citation: | Contrast Media and Molecular Imaging 11(3): 203-210 (2016) | Abstract: | Combination of complementary imaging techniques, like hybrid PET/MRI, allows protocols to be developed that exploit the best features of both. In order to get the best of these combinations the use of dual probes is highly desirable. On this sense the combination of biocompatible iron oxide nanoparticles and 68Ga isotope is a powerful development for the new generation of hybrid systems and multimodality approaches. Our objective was the synthesis and application of a chelator-free 68Ga-iron oxide nanotracer with improved stability, radiolabeling yield and in vivo performance in dual PET/MRI. We carried out the core doping of iron oxide nanoparticles, without the use of any chelator, by a microwave-driven protocol. The synthesis allowed the production of extremely small (2.5 nm) 68Ga core-doped iron oxide nanoparticles. The microwave approach allowed an extremely fast synthesis with a 90% radiolabeling yield and T1 contrast in MRI. With the same microwave approach the nano-radiotracer was functionalized in a fast and efficient way. We finally evaluated these dual targeting nanoparticles in an angiogenesis murine model by PET/MR imaging. | Publisher version (URL): | https://doi.org/10.1002/cmmi.1681 | URI: | http://hdl.handle.net/10261/186159 | DOI: | 10.1002/cmmi.1681 | Identifiers: | doi: 10.1002/cmmi.1681 e-issn: 1555-4317 issn: 1555-4309 |
Appears in Collections: | (ICMM) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
fast_synthesis_bioconjugation_morales_2016.pdf | 1,64 MB | Adobe PDF | ![]() View/Open |
Review this work
SCOPUSTM
Citations
53
checked on Jul 2, 2022
WEB OF SCIENCETM
Citations
52
checked on Jun 30, 2022
Page view(s)
171
checked on Jul 6, 2022
Download(s)
46
checked on Jul 6, 2022
Google ScholarTM
Check
Altmetric
Dimensions
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.