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Title

Clay-lipid nanohybrids: towards influenza vaccines and beyond

AuthorsWicklein, Bernd ; Darder, Margarita ; Aranda, Pilar ; Martín del Burgo, M. Ángeles; Real, Gustavo del; Esteban, Mariano; Ruiz-Hitzky, Eduardo
KeywordsVaccine
Adjuvant
Immunization
Influenza virus
Clay-lipid hybrid
Issue DateSep-2016
PublisherOxford University Press
CitationClay Minerals 51(4): 529-538 (2016)
AbstractThe design of nanostructured materials based on natural components, such as clay minerals, offers new solutions to biomedical challenges such as more efficient and storage-stable vaccines. Clay-lipid hybrid materials have proved useful as adjuvants in influenza vaccines and with a possible projection to leishmaniasis vaccines and other pathogens. Self-assembly of phospholipid molecules on the surface of microfibrous sepiolite and lamellar Mg/Al layered double hydroxide renders a biocompatible lipid bilayer membrane that ensures non-degrading immobilization of proteins and other biological species including viral particles and DNA (deoxyribonucleic acid). Immunization tests in mice showed the superior immunogenicity of a clay-lipid-supported virus compared to a commercial aluminium hydroxide adjuvant.
URIhttp://hdl.handle.net/10261/186144
Identifiersdoi: 10.1180/claymin.2016.051.4.01
issn: 0009-8558
e-issn: 1471-8030
Appears in Collections:(CNB) Artículos
(ICMM) Artículos
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