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Título

Anti-heat shock protein 90β antibodies are detected in patients with multiple sclerosis during remission

AutorCid, Cristina ; Regidor, I.; Alcázar, Alberto
Palabras claveAutoantibodies
Cerebrospinal fluid
Hsp90
Multiple sclerosis
Remission
Western blot
Fecha de publicaciónmar-2007
EditorElsevier
CitaciónJournal of Neuroimmunology 184(1-2): 223-226 (2007)
ResumenAntibodies against heat shock protein 90β (Hsp90β) recognize the antigen on the surface of oligodendrocyte precursor cells and induce a decrease in the oligodendrocyte population of cell cultures. This study investigated the presence of anti-Hsp90β antibodies in patients with multiple sclerosis (MS) during remission. Anti-Hsp90β antibodies were detected in the cerebrospinal fluid (CSF) of patients with a specific and sensitive western blot procedure using Hsp90β from cell membrane fraction. The number of patients with anti-Hsp90β antibodies detected in the CSF was significantly greater in MS patients than in control patients with other neurological diseases, which included patients with other inflammatory neurological diseases. CSF anti-Hsp90β antibody levels were significantly higher in MS patients than in control patients. The presence of anti-Hsp90β antibodies in the CSF of MS patients during remission could suggest a potential pathogenic role for these autoantibodies in MS.
Descripción4 pages, 2 figures.-- Available online 11 Dec. 2006.
Versión del editorhttp://dx.doi.org/10.1016/j.jneuroim.2006.11.001
URIhttp://hdl.handle.net/10261/18582
DOI10.1016/j.jneuroim.2006.11.001
ISSN0165-5728
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