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dc.contributor.authorDiezma-Navas, Lauraes_ES
dc.contributor.authorPérez-González, Anaes_ES
dc.contributor.authorArtaza-Álvarez, Haydeées_ES
dc.contributor.authorAlonso, Lolaes_ES
dc.contributor.authorCaro, Elenaes_ES
dc.contributor.authorLlave, Césares_ES
dc.contributor.authorRuiz-Ferrer, Virginiaes_ES
dc.identifier.citationMolecular plant pathology (2019)es_ES
dc.description14 p.-6 fig.es_ES
dc.description.abstractDNA methylation is an important epigenetic mechanism for controlling innate immunity against microbial pathogens in plants. Little is known, however, about the manner in which viral infections interact with DNA methylation pathways. Here we investigate the crosstalk between epigenetic silencing and viral infections in Arabidopsis inflorescences. We found that tobacco rattle virus (TRV) causes changes in the expression of key transcriptional gene silencing factors with RNA‐directed DNA methylation activities that coincide with changes in methylation at the whole genome level. Viral susceptibility/resistance was altered in DNA (de)methylation‐deficient mutants, suggesting that DNA methylation is an important regulatory system controlling TRV proliferation. We further show that several transposable elements (TEs) underwent transcriptional activation during TRV infection, and that TE regulation likely involved both DNA methylation‐dependent and ‐independent mechanisms. We identified a cluster of disease resistance genes regulated by DNA methylation in infected plants that were enriched for TEs in their promoters. Interestingly, TEs and nearby resistance genes were co‐regulated in TRV‐infected DNA (de)methylation mutants. Our study shows that DNA methylation contributes to modulate the outcome of viral infections in Arabidopsis, and opens up new possibilities for exploring the role of TE regulation in antiviral defence.es_ES
dc.description.sponsorshipThis work has been supported by a Ramon y Cajal grant (RyC‐2011‐07006) to VRF and by National Research grants BIO2012‐39973 and BIO2015‐70752‐R to CL from Ministerio de Economía y Competitividad (MINECO/FEDER), Spain.es_ES
dc.publisherJohn Wiley & Sonses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectArabidopsis thalianaes_ES
dc.subjectDisease resistance geneses_ES
dc.subjectDNA methylationes_ES
dc.subjectPlant–virus interactionses_ES
dc.subjectPlant viruseses_ES
dc.subjectRNA-dependent DNA methylationes_ES
dc.subjectTobacco rattle viruses_ES
dc.subjectTransposable elementses_ES
dc.titleCrosstalk between epigenetic silencing and infection by tobacco rattle virus in Arabidopsises_ES
dc.description.peerreviewedPeer reviewedes_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
oprm.item.hasRevisionno ko 0 false*
dc.contributor.orcidDiezma-Navas, Laura [0000-0001-5857-5091]es_ES
dc.contributor.orcidPérez-González, Ana [0000-0002-7724-9985]es_ES
dc.contributor.orcidArtaza-Álvarez, Haydeé [0000-0002-1585-5488]es_ES
dc.contributor.orcidAlonso, Lola [0000-0002-3493-718X]es_ES
dc.contributor.orcidCaro, Elena [0000-0002-1034-1621 ]es_ES
dc.contributor.orcidLlave, César [0000-0003-3844-4582]es_ES
dc.contributor.orcidRuiz-Ferrer, Virginia [0000-0002-7840-297X]es_ES
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