English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/185731
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Closing the DNA replication cycle: from simple circular molecules to supercoiled and knotted DNA catenanes

AuthorsSchvartzman, Jorge Bernardo ; Hernandez, Pablo ; Krimer, Dora B. ; Dorier, Julien; Stasiak, Andrzej Z.
Issue Date5-Jul-2019
PublisherOxford University Press
CitationNucleic Acids Research, gkz586 (2019)
AbstractDue to helical structure of DNA, massive amounts of positive supercoils are constantly introduced ahead of each replication fork. Positive supercoiling inhibits progression of replication forks but various mechanisms evolved that permit very efficient relaxation of that positive supercoiling. Some of these mechanisms lead to interesting topological situations where DNA supercoiling, catenation and knotting coexist and influence each other in DNA molecules being replicated. Here, we first review fundamental aspects of DNA supercoiling, catenation and knotting when these qualitatively different topological states do not coexist in the same circular DNA but also when they are present at the same time in replicating DNA molecules. We also review differences between eukaryotic and prokaryotic cellular strategies that permit relaxation of positive supercoiling arising ahead of the replication forks. We end our review by discussing very recent studies giving a long-sought answer to the question of how slow DNA topoisomerases capable of relaxing just a few positive supercoils per second can counteract the introduction of hundreds of positive supercoils per second ahead of advancing replication forks.
Description17 p.-10 fig.
Publisher version (URL)https://doi.org/10.1093/nar/gkz586
URIhttp://hdl.handle.net/10261/185731
DOI10.1093/nar/gkz586
ISSN0305-1048
E-ISSN1362-4962
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
Nucleic Acids Research_Schvartzman_2019.pdfArtículo principal2,56 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.