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Title

Modulation of the eps-ome transcription of bifidobacteria through simulation of human intestinal environment

AuthorsFerrario, Chiara; Milani, Christian; Mancabelli, Leonardo; Lugli, Gabriele Andrea; Duranti, Sabrina; Mangifesta, Marta; Viappiani, Alice; Turroni, Francesca; Margolles Barros, Abelardo ; Ruas-Madiedo, Patricia ; Van Sinderen, Douwe; Ventura, Marco
KeywordsBifidobacterium
Exopolysaccharide
Genomics
RNAseq
Gut microbiota
Issue Date8-Mar-2016
PublisherOxford University Press
CitationFEMS Microbiology Ecology 2(4): fiw056 (2016)
AbstractBacterial exopolysaccharides (EPSs) are mono- or oligo-saccharide units linked by glycosidic bonds, forming homo- or hetero-polymers. In gut commensals, these macromolecules are claimed to protect bacterial cells against gastrointestinal challenges and to be involved in modulating the cross talk between the producing bacterium and its gut environment. The predicted EPS arsenal of the Bifidobacterium genus, which we designate here as the eps-ome, consists of 9 eps gene clusters conserved among different bifidobacterial species and a further 44 unique eps loci, together representing a large proportion of the inter(sub)species variability identified among bifidobacterial genomes. Co-cultivations of bifidobacterial species in media simulating adult and infant human gut environments resulted in an increased transcription of key genes for EPS biosynthesis, including glycosyltransferase-encoding genes, as well as genes specifying EPS transporter and polymerase functions, and saccharide biosynthesis and modification enzymes.
Publisher version (URL)http://dx.doi.org/10.1093/femsec/fiw056
URIhttp://hdl.handle.net/10261/184902
DOI10.1093/femsec/fiw056
ISSN0168-6496
E-ISSN1574-6941
Appears in Collections:(IPLA) Artículos
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