English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/184888
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorFernández-Moreira, Vanesaes_ES
dc.contributor.authorSastre-Martín, Héctores_ES
dc.date.accessioned2019-06-26T11:10:44Z-
dc.date.available2019-06-26T11:10:44Z-
dc.date.issued2017-
dc.identifier.citationInorganica Chimica Acta 460: 127-133 (2017)es_ES
dc.identifier.issn0020-1693-
dc.identifier.urihttp://hdl.handle.net/10261/184888-
dc.description.abstractLuminescent fac-rhenium(I) derivatives have proven their great potential as cell imaging agents. However, there is still a lack of information regarding the structure-bioactivity and biodistribution relationship specially in those cases where the axial ligand is a S-donor ligand. Therefore, new [Re(bipy)(CO)3L]0/+ complexes, where L is pyridine-4-thiolate (L1), pyridine-2-thiolate (L2) and 6-methylpyridine-2(1H)thione (L3) were synthesised. The ditopic thiol/thione-pyridine derivatives (Spy derivatives) behaved as sulfur donor in all cases, affording two neutral (1 and 2) and a cationic (3) complex respectively. X-ray diffraction revealed the different coordination mode presented by L2 and L3, a thiolate and a thione donor respectively. Photophysical studies showed that they have moderate emission intensities that are tentatively assigned to 3MLCT transitions (1, 2) and a mixture of 1IL and 3MLCT transition (3) with lifetimes in the ns range. Possibly the presence of both, donor and acceptor ligands, SPy and bipyridine respectively, is facilitating a non-radiative LLCT transition to take place, which diminishes the probability of dissipating the energy by a radiative 3MLCT transition. In addition, cytotoxicity assays performed in human cancerous A549 lung and HeLa cervix cells disclosed their poor cytotoxic activity (IC50 > 100 μM), which would enable their applications in cell imaging. However, confocal cell microscopy studies performed in A549 cells were not decisive; probably the low emission intensity prevented a clear visualization of the probe.es_ES
dc.description.sponsorshipAuthors thank the Ministerio de Economía y Competitividad (MINECO-FEDER CTQ2013-48635-C2-1-P, and CTQ2015-70371-REDT) and Gobierno de Aragón-Fondo Social Europeo (E77) for financial support.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationMINECO/ICTI2013-2016/CTQ2013-48635-C2-1-Pes_ES
dc.relationMINECO/ICTI2013-2016/CTQ2015-70371-REDTes_ES
dc.rightsclosedAccesses_ES
dc.subjectRheniumes_ES
dc.subjectThiolatees_ES
dc.subjectThionees_ES
dc.subjectLuminescencees_ES
dc.subjectCytotoxicityes_ES
dc.subjectCell imaginges_ES
dc.titlePhotophysical and bioactivity behavior of fac-rhenium(I) derivatives containing ditopic sulfurpyridine ligandses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.ica.2016.07.038-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.ica.2016.07.038es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderGobierno de Aragónes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100010067es_ES
Appears in Collections:(ISQCH) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf59,24 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.