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dc.contributor.authorFernández-García, Lauraes_ES
dc.contributor.authorFernández-Cuenca, Felipees_ES
dc.contributor.authorBlasco, Lucíaes_ES
dc.contributor.authorLópez-Rojas, Rafaeles_ES
dc.contributor.authorAmbroa, Antónes_ES
dc.contributor.authorLópez, Maríaes_ES
dc.contributor.authorPascual, Álvaroes_ES
dc.contributor.authorBou, Germánes_ES
dc.contributor.authorTomás, Maríaes_ES
dc.date.accessioned2019-06-21T07:28:20Z-
dc.date.available2019-06-21T07:28:20Z-
dc.date.issued2018-05-
dc.identifier.citationAntimicrobial Agents and Chemotherapy 62: e00250-18 (2018)es_ES
dc.identifier.issn0066-4804-
dc.identifier.urihttp://hdl.handle.net/10261/184549-
dc.description.abstractThe molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.es_ES
dc.description.sponsorshipThis study was funded by grants PI13/02390 and PI16/01163, awarded to M.T., and by grant PI11-02046, awarded to F.F.-C., within the State Plan for R+D+I 2013–2016 (National Plan for Scientific Research, Technological Development and Innovation 2008–2011) and cofinanced by the ISCIII-Deputy General Directorate of Evaluation and Promotion of Research—European Regional Development Fund “A Way of Making Europe” and the Instituto de Salud Carlos III FEDER, Spanish Network for the Research in Infectious Diseases (REIPI, grants RD12/0015/0010 and RD16/0016/0001), as well as by the Study Group on Mechanisms of Action and Resistance to Antimicrobials, GEMARA (SEIMC). M.T. was financially supported by the Miguel Servet Research Programme (SERGAS and ISCIII). L.F.-G. was financially supported by a predoctoral fellowship from the Xunta de Galicia (GAIN, Axencia de Innovación).es_ES
dc.language.isoenges_ES
dc.publisherAmerican Society for Microbiologyes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectTolerancees_ES
dc.subjectPersistencees_ES
dc.subjectChlorhexidinees_ES
dc.subjectImipenemes_ES
dc.subjectAcinetobacteres_ES
dc.subjectToxin-antitoxines_ES
dc.titleRelationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin Systemes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1128/AAC.00250-18-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1128/AAC.00250-18es_ES
dc.identifier.e-issn1098-6596-
dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderXunta de Galiciaes_ES
dc.relation.csicSíes_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100010801es_ES
dc.identifier.pmid29463538-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeartículo-
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