English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/184549
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System

AuthorsFernández-García, Laura; Fernández-Cuenca, Felipe; Blasco, Lucía; López-Rojas, Rafael; Ambroa, Antón; López, María; Pascual, Álvaro; Bou, Germán; Tomás, María
KeywordsTolerance
Persistence
Chlorhexidine
Imipenem
Acinetobacter
Toxin-antitoxin
Issue DateMay-2018
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 62: e00250-18 (2018)
AbstractThe molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.
Publisher version (URL)https://doi.org/10.1128/AAC.00250-18
URIhttp://hdl.handle.net/10261/184549
DOI10.1128/AAC.00250-18
ISSN0066-4804
E-ISSN1098-6596
Appears in Collections:(IBIS) Artículos
Files in This Item:
File Description SizeFormat 
antimicrobial_agents.pdf825,14 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.