Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/18451
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Oliver, Eduardo | - |
dc.contributor.author | Martí, Daniel | - |
dc.contributor.author | Montó, Fermí | - |
dc.contributor.author | Flacco, Nicla | - |
dc.contributor.author | Moreno, Lucrecia | - |
dc.contributor.author | Barettino, Domingo | - |
dc.contributor.author | Ivorra, M. Dolores | - |
dc.contributor.author | D'Ocón, Pilar | - |
dc.date.accessioned | 2009-11-10T12:31:21Z | - |
dc.date.available | 2009-11-10T12:31:21Z | - |
dc.date.issued | 2009-03 | - |
dc.identifier.citation | Journal of Pharmacology and Experimental Therapeutics 328(3):982-90 (2009) | en_US |
dc.identifier.issn | 0022-3565 | - |
dc.identifier.uri | http://hdl.handle.net/10261/18451 | - |
dc.description | 9 pages, 7 figures, 3 tables.-- PMID: 19060223 [PubMed] | en_US |
dc.description.abstract | In human and animal hypertension models, increased activity of G-protein-coupled receptor kinase (GRK) 2 determines a generalized decrease of beta-adrenergic vasodilatation. We analyzed the possibility of differential changes in the expression and functionality of alpha(1A), alpha(1B), alpha(1D), beta(1), beta(2), and beta(3)-ARs also being involved in the process. We combined the quantification of mRNA levels with immunoblotting and functional studies in aortas of young and adult spontaneously hypertensive rats (SHRs) and their controls (Wistar Kyoto). We found the expression and function of beta(1)-adrenoceptors in young prehypertensive SHRs to be higher, whereas a generalized increase in the expression of the six adrenoceptors and GRK2 was observed in aortas of adult hypertensive SHRs. alpha(1D)- and beta(3)-adrenoceptors, the subtypes that are more resistant to GRK2-mediated internalization and mostly expressed in rat aorta, exhibited an increased functional role in hypertensive animals, showing two hemodynamic consequences: 1) an increased sensitivity to the vasoconstrictor stimulus accompanied by a decreased sensitivity to the vasodilator stimulus (alpha(1D)-ARs are the most sensitive to agonists, and beta(3)-ARs are the least sensitive to agonists); and 2) a slower recovery of the basal tone after adrenergic stimulus removal because of the kinetic characteristic of the alpha(1D) subtype. These functional changes might be involved in the greater sympathetic vasoconstrictor tone observed in hypertension. | en_US |
dc.description.sponsorship | This work was supported by the Spanish Comisión Interministerial de Ciencia y Tecnología [Grant SAF2004-01541]; Generalitat Valenciana [Grants GV2004-B-085, GRUPOS05-038]; and Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias [Grant FIS PI070509]; and by the Spanish Ministry of Education and Science [Fellowships AP-2004-3536 and AP-2005-5076]. | en_US |
dc.format.extent | 15595 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | American Society for Pharmacology and Experimental Therapeutics | en_US |
dc.rights | closedAccess | en_US |
dc.title | The impact of alpha1-adrenoceptors up-regulation accompanied by the impairment of beta-adrenergic vasodilatation in hypertension | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1124/jpet.108.146043 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1124/jpet.108.146043 | en_US |
dc.identifier.e-issn | 1521-0103 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (IBV) Artículos |
CORE Recommender
SCOPUSTM
Citations
34
checked on 16-abr-2024
WEB OF SCIENCETM
Citations
33
checked on 23-feb-2024
Page view(s)
377
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.