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Título

Evolutionary constraints to viroid evolution

AutorElena, Santiago F. ; Gómez, Gustavo; Daròs, José-Antonio
Palabras claveviroids
viroids evolution
epistasis
evolutionary constraints
genome complexity
RNA folding
Fecha de publicación2009
EditorMultidisciplinary Digital Publishing Institute
CitaciónViruses 1: 241-254
ResumenWe suggest that viroids are trapped into adaptive peaks as the result of adaptive constraints. The first one is imposed by the necessity to fold into packed structures to escape from RNA silencing. This creates antagonistic epistases, which make future adaptive trajectories contingent upon the first mutation and slow down the rate of adaptation. This second constraint can only be surpassed by increasing genetic redundancy or by recombination. Eigen’s paradox imposes a limit to the increase in genome complexity in the absence of mechanisms reducing mutation rate. Therefore, recombination appears as the only possible route to evolutionary innovation in viroids.
Versión del editorhttp://dx.doi.org/10.3390/v1020241
URIhttp://hdl.handle.net/10261/18450
DOI10.3390/v1020241
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