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Title

Plasmidic qnr Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions

AuthorsMartín-Gutiérrez, Guillermo; Rodríguez-Martínez, José-Manuel; Pascual, Álvaro; Rodríguez Beltrán, Jerónimo; Blázquez Gómez, Jesús
KeywordsCiprofloxacin
Escherichia coli
MIC
pH
qnr
Urinary tract infection
Issue Date2017
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 61: 02615-16 (2017)
AbstractEscherichia coli variants expressing plasmid-mediated qnr genes are usually susceptible to fluoroquinolones by standard susceptibility testing. Here we show that, under specific urinary tract physiological conditions, susceptible laboratory and clinical strains harboring qnr determinants become fully resistant to ciprofloxacin (CIP). Therefore, physiological conditions, mainly urine pH values, should be considered when performing susceptibility testing of CIP activity against E. coli in treating urinary tract infection (UTI) and for selecting appropriate antibiotics for UTI treatment.
Publisher version (URL)https://doi.org/10.1128/AAC.02615-16
URIhttp://hdl.handle.net/10261/184322
DOI10.1128/AAC.02615-16
ISSN0066-4804
E-ISSN1098-6596
Appears in Collections:(IBIS) Artículos
(CNB) Artículos
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