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Título: | Plasmidic qnr Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions |
Autor: | Martín-Gutiérrez, Guillermo CSIC ORCID; Rodríguez-Martínez, José-Manuel CSIC ORCID; Pascual, Álvaro CSIC ORCID; Rodríguez Beltrán, Jerónimo CSIC ORCID; Blázquez Gómez, Jesús CSIC ORCID | Palabras clave: | Ciprofloxacin Escherichia coli MIC pH qnr Urinary tract infection |
Fecha de publicación: | 2017 | Editor: | American Society for Microbiology | Citación: | Antimicrobial Agents and Chemotherapy 61: 02615-16 (2017) | Resumen: | Escherichia coli variants expressing plasmid-mediated qnr genes are usually susceptible to fluoroquinolones by standard susceptibility testing. Here we show that, under specific urinary tract physiological conditions, susceptible laboratory and clinical strains harboring qnr determinants become fully resistant to ciprofloxacin (CIP). Therefore, physiological conditions, mainly urine pH values, should be considered when performing susceptibility testing of CIP activity against E. coli in treating urinary tract infection (UTI) and for selecting appropriate antibiotics for UTI treatment. | Versión del editor: | https://doi.org/10.1128/AAC.02615-16 | URI: | http://hdl.handle.net/10261/184322 | DOI: | 10.1128/AAC.02615-16 | ISSN: | 0066-4804 | E-ISSN: | 1098-6596 |
Aparece en las colecciones: | (IBIS) Artículos (CNB) Artículos |
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