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A single picture explains diversity of hyperthermia response of magnetic nanoparticles

AuthorsConde-Leboran, Ivan; Baldomir, Daniel; Martinez-Boubeta, Carlos; Chubykalo-Fesenko, O. ; Morales, M. P. ; Salas, Gorka; Cabrera, David; Camarero, Julio; Teran, Francisco José; Serantes, David
Issue Date9-Jul-2015
PublisherAmerican Chemical Society
CitationJournal of Physical Chemistry C 119(27): 15698-15706 (2015)
AbstractProgress in the design of nanoscale magnets for localized hyperthermia cancer therapy has been largely driven by trial-and-error approaches, for instance, by changing of the stoichiometry composition, size, and shape of the magnetic entities. So far, widely different and often conflicting heat dissipation results have been reported, particularly as a function of the nanoparticle concentration. Thus, achieving hyperthermia-efficient magnetic ferrofluids remains an outstanding challenge. Here we demonstrate that diverging heat-dissipation patterns found in the literature can be actually described by a single picture accounting for both the intrinsic magnetic features of the particles (anisotropy, magnetization) and experimental conditions (concentration, magnetic field). Importantly, this general magnetic-hyperthermia scenario also predicts a novel non-monotonic concentration dependence with optimum heating features, which we experimentally confirmed in iron oxide nanoparticle ferrofluids by fine-tuning the particle size. Overall, our approach implies a magnetic hyperthermia trilemma that may constitute a simple strategy for development of magnetic nanomaterials for optimal hyperthermia efficiency.
Publisher version (URL)https://doi.org/10.1021/acs.jpcc.5b02555
Identifiersdoi: 10.1021/acs.jpcc.5b02555
e-issn: 1932-7455
issn: 1932-7447
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(ICMM) Artículos
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