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Polyethylenimine-coated SPION exhibits potential intrinsic anti-metastatic properties inhibiting migration and invasion of pancreatic tumor cells

AuthorsMulens-Arias, Vladimir; Rojas, J. M.; Pérez-Yagüe, Sonia; Morales, M. P. ; Barber, Domingo F.
KeywordsTumor cell migration
Tumor cell invasion
Matrix degradation
Issue Date25-Oct-2015
CitationJournal of controlled release 216: 78-92 (2015)
AbstractDue to its aggressive behavior, pancreatic cancer is one of the principal causes of cancer-related deaths. The highly metastatic potential of pancreatic tumor cells demands the development of more effective anti-metastatic approaches for this disease. Although polyethylenimine-coated superparamagnetic iron oxide nanoparticles (PEI-coated SPIONs) have been studied for their utility as transfection agents, little is known of their effect on tumor cell biology. Here we demonstrated that PEI-coated SPIONs have potent inhibitory effects on pancreatic tumor cell migration/invasion, through inhibition of Src kinase and decreased expression of MT1-MMP and MMP2 metalloproteinases. When treated with PEI-coated SPIONs, the pancreatic tumor cell line Pan02 showed reduced invadosome density and thus, a decrease in their ability to invade through basement membrane. These nanoparticles temporarily downmodulated microRNA-21, thereby upregulating the cell migration inhibitors PTEN, PDCD4 and Sprouty-1. PEI-coated SPIONs thus show intrinsic, possibly anti-metastatic properties for modulating pancreatic tumor cell migration machinery, which indicates their potential as anti-metastatic agents for treatment of pancreatic cancer.
Publisher version (URL)https://doi.org/10.1016/j.jconrel.2015.08.009
Identifiersdoi: 10.1016/j.jconrel.2015.08.009
e-issn: 1873-4995
issn: 0168-3659
Appears in Collections:(ICMM) Artículos
(CNB) Artículos
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